British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV
Introduction Women living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a combination of viral factors, gender differences, hormonal imbalance and psychosocial and structural cond...
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BMJ Publishing Group
2021-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/8/e046558.full |
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| author | Joel Singer Melanie Lee Angela Kaida Neora Pick Valerie Nicholson Rebecca Gormley Shayda A Swann Jason Brophy Amber R Campbell Allison Carter Chelsea Elwood Tsion Gebremedhen Elizabeth M King Vonnie Lee Evelyn J Maan Patience Magagula Sheila Nyman Davi Pang Tetiana Povshedna Jerilynn C Prior Shelly Tognazzini Melanie C M Murray Helene C F Cote |
| author_facet | Joel Singer Melanie Lee Angela Kaida Neora Pick Valerie Nicholson Rebecca Gormley Shayda A Swann Jason Brophy Amber R Campbell Allison Carter Chelsea Elwood Tsion Gebremedhen Elizabeth M King Vonnie Lee Evelyn J Maan Patience Magagula Sheila Nyman Davi Pang Tetiana Povshedna Jerilynn C Prior Shelly Tognazzini Melanie C M Murray Helene C F Cote |
| author_sort | Joel Singer |
| collection | DOAJ |
| description | Introduction Women living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a combination of viral factors, gender differences, hormonal imbalance and psychosocial and structural conditions. This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysis The British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. A subset of BCC3 participants will be past participants of CARMA, n≥1000 women and children living with and without HIV, 2008–2018 and/or CHIWOS, n=1422 WLWH, 2013–2018. Over two study visits, we will collect biological specimens for virus serologies, hormones and biological markers as well as administer a survey capturing demographic and sociostructural–behavioural factors. Sociodemographics, comorbidities, number and type of chronic/latent viral infections and hormonal irregularities will be compared between the two groups. Their association with biological markers and psychostructural and sociostructural factors will be investigated through multivariable regression and structural equation modelling. Retrospective longitudinal analyses will be conducted on data from past CARMA/CHIWOS participants. As BCC3 aims to follow participants as they age, this protocol will focus on the first study visits.Ethics and dissemination This study has been approved by the University of British Columbia Children’s and Women’s Research Ethics Board (H19-00896). Results will be shared in peer-reviewed journals, conferences and at community events as well as at www.hivhearme.ca and @HIV_HEAR_me. WLWH are involved in study design, survey creation, participant recruitment, data collection and knowledge translation. A Community Advisory Board will advise the research team throughout the study. |
| format | Article |
| id | doaj-art-695f49110ead43fc929fa424dc6d0ced |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-695f49110ead43fc929fa424dc6d0ced2025-08-20T02:31:21ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-046558British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIVJoel Singer0Melanie Lee1Angela Kaida2Neora Pick3Valerie Nicholson4Rebecca Gormley5Shayda A Swann6Jason Brophy7Amber R Campbell8Allison Carter9Chelsea Elwood10Tsion Gebremedhen11Elizabeth M King12Vonnie Lee13Evelyn J Maan14Patience Magagula15Sheila Nyman16Davi Pang17Tetiana Povshedna18Jerilynn C Prior19Shelly Tognazzini20Melanie C M Murray21Helene C F Cote22Population and Public Health, University of British Columbia, Vancouver, British Columbia, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada10 Department of Medicine, The University of British Columbia, Vancouver, British Columbia, CanadaEpidemiology and Population Health, BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada1 Experimental Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada5 Division of Infectious Diseases, Childrens Hospital of Eastern Ontario, Ottawa, Ontario, Canada2 British Columbia Womens Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada2 British Columbia Womens Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada2 British Columbia Womens Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada2 British Columbia Womens Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada2 British Columbia Womens Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada10 Afro-Caribbean Positive Network of BC, Vancouver, British Columbia, Canada11 Bear Rock Consulting, Lone Butte, British Columbia, Canada3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada13 Pathology and Laboratory Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada7Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Canada3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada10 Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada2 British Columbia Womens Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, CanadaIntroduction Women living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a combination of viral factors, gender differences, hormonal imbalance and psychosocial and structural conditions. This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysis The British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. A subset of BCC3 participants will be past participants of CARMA, n≥1000 women and children living with and without HIV, 2008–2018 and/or CHIWOS, n=1422 WLWH, 2013–2018. Over two study visits, we will collect biological specimens for virus serologies, hormones and biological markers as well as administer a survey capturing demographic and sociostructural–behavioural factors. Sociodemographics, comorbidities, number and type of chronic/latent viral infections and hormonal irregularities will be compared between the two groups. Their association with biological markers and psychostructural and sociostructural factors will be investigated through multivariable regression and structural equation modelling. Retrospective longitudinal analyses will be conducted on data from past CARMA/CHIWOS participants. As BCC3 aims to follow participants as they age, this protocol will focus on the first study visits.Ethics and dissemination This study has been approved by the University of British Columbia Children’s and Women’s Research Ethics Board (H19-00896). Results will be shared in peer-reviewed journals, conferences and at community events as well as at www.hivhearme.ca and @HIV_HEAR_me. WLWH are involved in study design, survey creation, participant recruitment, data collection and knowledge translation. A Community Advisory Board will advise the research team throughout the study.https://bmjopen.bmj.com/content/11/8/e046558.full |
| spellingShingle | Joel Singer Melanie Lee Angela Kaida Neora Pick Valerie Nicholson Rebecca Gormley Shayda A Swann Jason Brophy Amber R Campbell Allison Carter Chelsea Elwood Tsion Gebremedhen Elizabeth M King Vonnie Lee Evelyn J Maan Patience Magagula Sheila Nyman Davi Pang Tetiana Povshedna Jerilynn C Prior Shelly Tognazzini Melanie C M Murray Helene C F Cote British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV BMJ Open |
| title | British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV |
| title_full | British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV |
| title_fullStr | British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV |
| title_full_unstemmed | British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV |
| title_short | British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV |
| title_sort | british columbia carma chiwos collaboration bcc3 protocol for a community collaborative cohort study examining healthy ageing with and for women living with hiv |
| url | https://bmjopen.bmj.com/content/11/8/e046558.full |
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