Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial
Background. The objective of this study was to evaluate the efficacy of adding single doses of ceftriaxone and amikacin to a ciprofloxacin plus metronidazole regimen on the reduction of infectious complications following transrectal ultrasound-guided prostate biopsy (TRUS Bx). Materials and Methods....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2017/4635386 |
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| author | Mohammad-Hossein Izadpanahi Kia Nouri-Mahdavi Seyed Mahmood Majidi Mohammad-Hatef Khorrami Farshid Alizadeh Mehrdad Mohammadi-Sichani |
| author_facet | Mohammad-Hossein Izadpanahi Kia Nouri-Mahdavi Seyed Mahmood Majidi Mohammad-Hatef Khorrami Farshid Alizadeh Mehrdad Mohammadi-Sichani |
| author_sort | Mohammad-Hossein Izadpanahi |
| collection | DOAJ |
| description | Background. The objective of this study was to evaluate the efficacy of adding single doses of ceftriaxone and amikacin to a ciprofloxacin plus metronidazole regimen on the reduction of infectious complications following transrectal ultrasound-guided prostate biopsy (TRUS Bx). Materials and Methods. Four hundred and fifty patients who were candidates for TRUS Bx were divided into two groups of 225 each. The control group received ciprofloxacin 500 mg orally every 12 hours together with metronidazole 500 mg orally every 8 hours from the day prior to the procedure until the fifth postoperative day. In the second group, single doses of ceftriaxone 1 g by intravenous infusion and amikacin 5 mg/kg intramuscularly were administered 30–60 minutes before TRUS Bx in addition to the oral antimicrobials described for group 1. The incidence of infection was compared between the groups. Results. The incidence of infectious complications in the intervention group was significantly lower than that in the control group (4.6% versus 0.9%, p=0.017). Conclusion. The addition of single doses of intramuscular amikacin and intravenously infused ceftriaxone to our prophylactic regimen of ciprofloxacin plus metronidazole resulted in a statistically significant reduction of infectious complications following TRUS Bx. |
| format | Article |
| id | doaj-art-695d9d549a6444a4a9d29cfbe16be336 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-695d9d549a6444a4a9d29cfbe16be3362025-08-20T03:33:31ZengWileyAdvances in Urology1687-63691687-63772017-01-01201710.1155/2017/46353864635386Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled TrialMohammad-Hossein Izadpanahi0Kia Nouri-Mahdavi1Seyed Mahmood Majidi2Mohammad-Hatef Khorrami3Farshid Alizadeh4Mehrdad Mohammadi-Sichani5Department of Urology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Urology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Urology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Urology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Urology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Urology, Isfahan University of Medical Sciences, Isfahan, IranBackground. The objective of this study was to evaluate the efficacy of adding single doses of ceftriaxone and amikacin to a ciprofloxacin plus metronidazole regimen on the reduction of infectious complications following transrectal ultrasound-guided prostate biopsy (TRUS Bx). Materials and Methods. Four hundred and fifty patients who were candidates for TRUS Bx were divided into two groups of 225 each. The control group received ciprofloxacin 500 mg orally every 12 hours together with metronidazole 500 mg orally every 8 hours from the day prior to the procedure until the fifth postoperative day. In the second group, single doses of ceftriaxone 1 g by intravenous infusion and amikacin 5 mg/kg intramuscularly were administered 30–60 minutes before TRUS Bx in addition to the oral antimicrobials described for group 1. The incidence of infection was compared between the groups. Results. The incidence of infectious complications in the intervention group was significantly lower than that in the control group (4.6% versus 0.9%, p=0.017). Conclusion. The addition of single doses of intramuscular amikacin and intravenously infused ceftriaxone to our prophylactic regimen of ciprofloxacin plus metronidazole resulted in a statistically significant reduction of infectious complications following TRUS Bx.http://dx.doi.org/10.1155/2017/4635386 |
| spellingShingle | Mohammad-Hossein Izadpanahi Kia Nouri-Mahdavi Seyed Mahmood Majidi Mohammad-Hatef Khorrami Farshid Alizadeh Mehrdad Mohammadi-Sichani Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial Advances in Urology |
| title | Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial |
| title_full | Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial |
| title_fullStr | Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial |
| title_full_unstemmed | Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial |
| title_short | Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial |
| title_sort | addition of ceftriaxone and amikacin to a ciprofloxacin plus metronidazole regimen for preventing infectious complications of transrectal ultrasound guided prostate biopsy a randomized controlled trial |
| url | http://dx.doi.org/10.1155/2017/4635386 |
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