Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender
Our study aimed to analyze the correlation of cancer-related parameters with tumor regression grade (TRG) and disease-free survival (DFS) by gender in 192 rectal cancer patients operated on after neoadjuvant long-course chemoradiotherapy (LCCRT). Preoperative diagnostics revealed no significant g...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2024-01-01
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| Series: | Acta Clinica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/481883 |
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| author | Velda Smajlbegović Snježana Ramić Iva Kirac Meliha Solak Mekić Loris Ćurt Danko Velimir Vrdoljak |
| author_facet | Velda Smajlbegović Snježana Ramić Iva Kirac Meliha Solak Mekić Loris Ćurt Danko Velimir Vrdoljak |
| author_sort | Velda Smajlbegović |
| collection | DOAJ |
| description | Our study aimed to analyze the correlation of cancer-related parameters with tumor
regression grade (TRG) and disease-free survival (DFS) by gender in 192 rectal cancer patients operated
on after neoadjuvant long-course chemoradiotherapy (LCCRT). Preoperative diagnostics revealed
no significant gender differences in any clinical parameters other than obesity (p=0.031). We found
that slightly overweight men had a lower incidence of distant metastases (p=0.042). The post-LCCRT
pathologic finding showed that women had more positive lymph nodes (ypN, p=0.002) while no other
pathologic parameter differed significantly between the genders. Overall, a poor response to therapy correlated
with a shorter time to disease progression (p=0.002). Women achieved ypN0 in 50% of cases, but
only 27% had a good TRG compared to 40.5% of men (p=0.073). Women had a worse DFS than men,
even when complete response to therapy was achieved (p=0.003), and greater depth of residual tumor
invasion (ypT, p=0.035) and higher ypN (p=0.002) correlated with shorter DFS. Positive resection margins
(p<0.001), higher ypN stage (p=0.003), and poor TRG (p=0.025) correlated with shorter DFS in
men. We conclude that women have a poorer response to LCCRT with the possibility that therapeutic
approach to the neoadjuvant treatment of rectal cancer may be gender-specific. |
| format | Article |
| id | doaj-art-695bb93102744a3493eec558a153cd43 |
| institution | Kabale University |
| issn | 0353-9466 1333-9451 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj-art-695bb93102744a3493eec558a153cd432025-08-20T03:50:06ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512024-01-0163.3-452353210.20471/acc.2024.63.04.10Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient GenderVelda Smajlbegović0Snježana Ramić1Iva Kirac2Meliha Solak Mekić3Loris Ćurt4Danko Velimir Vrdoljak5Department of Oncology, Clinical Center, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaOncologic Pathology, Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaSurgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDivision of Oncology and Radiotherapy, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaSurgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaSurgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaOur study aimed to analyze the correlation of cancer-related parameters with tumor regression grade (TRG) and disease-free survival (DFS) by gender in 192 rectal cancer patients operated on after neoadjuvant long-course chemoradiotherapy (LCCRT). Preoperative diagnostics revealed no significant gender differences in any clinical parameters other than obesity (p=0.031). We found that slightly overweight men had a lower incidence of distant metastases (p=0.042). The post-LCCRT pathologic finding showed that women had more positive lymph nodes (ypN, p=0.002) while no other pathologic parameter differed significantly between the genders. Overall, a poor response to therapy correlated with a shorter time to disease progression (p=0.002). Women achieved ypN0 in 50% of cases, but only 27% had a good TRG compared to 40.5% of men (p=0.073). Women had a worse DFS than men, even when complete response to therapy was achieved (p=0.003), and greater depth of residual tumor invasion (ypT, p=0.035) and higher ypN (p=0.002) correlated with shorter DFS. Positive resection margins (p<0.001), higher ypN stage (p=0.003), and poor TRG (p=0.025) correlated with shorter DFS in men. We conclude that women have a poorer response to LCCRT with the possibility that therapeutic approach to the neoadjuvant treatment of rectal cancer may be gender-specific.https://hrcak.srce.hr/file/481883Rectal cancerNeoadjuvant chemoradiotherapyGenderTumor regression gradeDisease-free survival |
| spellingShingle | Velda Smajlbegović Snježana Ramić Iva Kirac Meliha Solak Mekić Loris Ćurt Danko Velimir Vrdoljak Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender Acta Clinica Croatica Rectal cancer Neoadjuvant chemoradiotherapy Gender Tumor regression grade Disease-free survival |
| title | Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender |
| title_full | Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender |
| title_fullStr | Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender |
| title_full_unstemmed | Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender |
| title_short | Tumor Response to Neoadjuvant Long-Course Chemoradiotherapy Depends on the Rectal Cancer Patient Gender |
| title_sort | tumor response to neoadjuvant long course chemoradiotherapy depends on the rectal cancer patient gender |
| topic | Rectal cancer Neoadjuvant chemoradiotherapy Gender Tumor regression grade Disease-free survival |
| url | https://hrcak.srce.hr/file/481883 |
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