Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities
PurposeThis study investigates the incidence, predictors, and preventive strategies for microvascular complications in type 2 diabetes patients in community settings.MethodsData were collected from 3,008 type 2 diabetes patients enrolled across 31 clinics in Beijing and Hebei. Prevalence and inciden...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1541663/full |
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| author | Zhaoxiang Liu Lianhao Zhou Wenhui Zhao Lixia Jin Jinping Zhang Yajing Zhang Yufeng Li Guixia Deng Jiquan He Xinghua Zhao Wenli Zheng Yong Tian Ji Wu Ji Wu Jianzhong Xiao Jianzhong Xiao Jiandong Gao Jiandong Gao |
| author_facet | Zhaoxiang Liu Lianhao Zhou Wenhui Zhao Lixia Jin Jinping Zhang Yajing Zhang Yufeng Li Guixia Deng Jiquan He Xinghua Zhao Wenli Zheng Yong Tian Ji Wu Ji Wu Jianzhong Xiao Jianzhong Xiao Jiandong Gao Jiandong Gao |
| author_sort | Zhaoxiang Liu |
| collection | DOAJ |
| description | PurposeThis study investigates the incidence, predictors, and preventive strategies for microvascular complications in type 2 diabetes patients in community settings.MethodsData were collected from 3,008 type 2 diabetes patients enrolled across 31 clinics in Beijing and Hebei. Prevalence and incidence of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN) were assessed. Predictors were identified using XGBoost and Cox regression, and the impact of lifestyle and multifactorial interventions (MFI) was analyzed.ResultsThe prevalence of DKD, DR, and DPN were 39.5%, 26.2%, and 27.1%, respectively, with incidences of 74, 21, and 28 per 1000-person year. XGBoost identified that diabetes duration, age, HbA1c, FBG, triglyceride, BP, serum creatinine, proteinuria, aspirin and statin use were associated with those microvascular complications. The risk of DKD increased more rapidly as HbA1c exceeded 7.5% and decreased as blood pressure was maintained below 120/70 mmHg. Cox regression models showed that community-based intervention, including lifestyle modifications, were associated with a lower risk of DR and DPN. The study also found that higher variability in HbA1c and albumin-to-creatinine ratio (ACR) was associated with an increased risk of microvascular complications.ConclusionsCommunity-based interventions significantly reduce the of DR and DPN, highlighting the need for individualized glycemic and BP management in primary care. The findings emphasize the importance of comprehensive management strategies to prevent the development and progression of microvascular complications in type 2 diabetes patients.Clinical trial registrationhttp://www.chictr.org.cn/, identifier ChiCTR-TRC-13003222. |
| format | Article |
| id | doaj-art-6959552baca040b8ba3a0f08618d0575 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-6959552baca040b8ba3a0f08618d05752025-08-20T02:49:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-03-011610.3389/fendo.2025.15416631541663Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communitiesZhaoxiang Liu0Lianhao Zhou1Wenhui Zhao2Lixia Jin3Jinping Zhang4Yajing Zhang5Yufeng Li6Guixia Deng7Jiquan He8Xinghua Zhao9Wenli Zheng10Yong Tian11Ji Wu12Ji Wu13Jianzhong Xiao14Jianzhong Xiao15Jiandong Gao16Jiandong Gao17Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, ChinaDepartment of Electronic Engineering, Tsinghua University, Beijing, ChinaDepartment of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, ChinaDepartment of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Endocrinology, Beijing Pinggu District Hospital, Beijing, ChinaDepartment of Endocrinology, Beijing Pinggu District Hospital, Beijing, ChinaDepartment of Endocrinology, Beijing Pinggu District Yukou Community Central Health Center, Beijing, ChinaDepartment of Endocrinology, Beijing Pinggu District Xiagezhuang Township Hospital, Beijing, ChinaDepartment of Endocrinology, Beijing Huairou District Yangsong Township Hospital, Beijing, ChinaDepartment of Endocrinology, Beijing Daxing District Yinghai Community Central Health Center, Beijing, ChinaDepartment of Endocrinology, Beijing Huairou Hospital, Beijing, ChinaDepartment of Electronic Engineering, Tsinghua University, Beijing, China0Center for Big Data and Clinical Research, Institute for Precision Medicine, Tsinghua University, Beijing, ChinaDepartment of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China1Center for Intelligent Healthcare, Institute for Precision Medicine, Tsinghua University, Beijing, ChinaDepartment of Electronic Engineering, Tsinghua University, Beijing, China0Center for Big Data and Clinical Research, Institute for Precision Medicine, Tsinghua University, Beijing, ChinaPurposeThis study investigates the incidence, predictors, and preventive strategies for microvascular complications in type 2 diabetes patients in community settings.MethodsData were collected from 3,008 type 2 diabetes patients enrolled across 31 clinics in Beijing and Hebei. Prevalence and incidence of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN) were assessed. Predictors were identified using XGBoost and Cox regression, and the impact of lifestyle and multifactorial interventions (MFI) was analyzed.ResultsThe prevalence of DKD, DR, and DPN were 39.5%, 26.2%, and 27.1%, respectively, with incidences of 74, 21, and 28 per 1000-person year. XGBoost identified that diabetes duration, age, HbA1c, FBG, triglyceride, BP, serum creatinine, proteinuria, aspirin and statin use were associated with those microvascular complications. The risk of DKD increased more rapidly as HbA1c exceeded 7.5% and decreased as blood pressure was maintained below 120/70 mmHg. Cox regression models showed that community-based intervention, including lifestyle modifications, were associated with a lower risk of DR and DPN. The study also found that higher variability in HbA1c and albumin-to-creatinine ratio (ACR) was associated with an increased risk of microvascular complications.ConclusionsCommunity-based interventions significantly reduce the of DR and DPN, highlighting the need for individualized glycemic and BP management in primary care. The findings emphasize the importance of comprehensive management strategies to prevent the development and progression of microvascular complications in type 2 diabetes patients.Clinical trial registrationhttp://www.chictr.org.cn/, identifier ChiCTR-TRC-13003222.https://www.frontiersin.org/articles/10.3389/fendo.2025.1541663/fulltype 2 diabetesmachine learningdiabetes kidney diseasediabetic retinopathydiabetic peripheral neuropathy |
| spellingShingle | Zhaoxiang Liu Lianhao Zhou Wenhui Zhao Lixia Jin Jinping Zhang Yajing Zhang Yufeng Li Guixia Deng Jiquan He Xinghua Zhao Wenli Zheng Yong Tian Ji Wu Ji Wu Jianzhong Xiao Jianzhong Xiao Jiandong Gao Jiandong Gao Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities Frontiers in Endocrinology type 2 diabetes machine learning diabetes kidney disease diabetic retinopathy diabetic peripheral neuropathy |
| title | Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities |
| title_full | Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities |
| title_fullStr | Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities |
| title_full_unstemmed | Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities |
| title_short | Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities |
| title_sort | predict and prevent microvascular complications of type 2 diabetes a cross sectional and longitudinal study in chinese communities |
| topic | type 2 diabetes machine learning diabetes kidney disease diabetic retinopathy diabetic peripheral neuropathy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1541663/full |
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