Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update
This review article highlights recent developments in the clinical pharmacology of statins. A thorough literature search was performed using PubMed Central, Scopus, and Google Scholar, focusing on keywords related to statin kinetics, mechanisms, cardiovascular protection, side effects, and variation...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2025-06-01
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| Series: | Libyan International Medical University Journal |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809043 |
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| _version_ | 1850218731712544768 |
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| author | Abdalla Salem Elhwuegi Mustafa M. Elfakhri |
| author_facet | Abdalla Salem Elhwuegi Mustafa M. Elfakhri |
| author_sort | Abdalla Salem Elhwuegi |
| collection | DOAJ |
| description | This review article highlights recent developments in the clinical pharmacology of statins. A thorough literature search was performed using PubMed Central, Scopus, and Google Scholar, focusing on keywords related to statin kinetics, mechanisms, cardiovascular protection, side effects, and variations in individual responses. Understanding the pharmacokinetics of statins is essential for maximizing their therapeutic effects while reducing side effects and potential drug interactions. Statins have varying degrees of lipophilicity, resulting in different kinetic profiles that affect their bioavailability, elimination, and interactions with other drugs. |
| format | Article |
| id | doaj-art-69580bdf20004bdf9ccb6e2417c6e261 |
| institution | OA Journals |
| issn | 2519-139X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Libyan International Medical University Journal |
| spelling | doaj-art-69580bdf20004bdf9ccb6e2417c6e2612025-08-20T02:07:37ZengThieme Medical and Scientific Publishers Pvt. Ltd.Libyan International Medical University Journal2519-139X2025-06-01100101802810.1055/s-0045-1809043Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An UpdateAbdalla Salem Elhwuegi0https://orcid.org/0000-0002-9763-9470Mustafa M. Elfakhri1Libyan International Medical University, Benghazi, LibyaFaculty of Medicine, Benghazi, LibyaThis review article highlights recent developments in the clinical pharmacology of statins. A thorough literature search was performed using PubMed Central, Scopus, and Google Scholar, focusing on keywords related to statin kinetics, mechanisms, cardiovascular protection, side effects, and variations in individual responses. Understanding the pharmacokinetics of statins is essential for maximizing their therapeutic effects while reducing side effects and potential drug interactions. Statins have varying degrees of lipophilicity, resulting in different kinetic profiles that affect their bioavailability, elimination, and interactions with other drugs.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809043cardiovascular protective effectspersonalized treatment of statinsstatin kineticsstatin side effectsstatins |
| spellingShingle | Abdalla Salem Elhwuegi Mustafa M. Elfakhri Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update Libyan International Medical University Journal cardiovascular protective effects personalized treatment of statins statin kinetics statin side effects statins |
| title | Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update |
| title_full | Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update |
| title_fullStr | Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update |
| title_full_unstemmed | Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update |
| title_short | Pharmacological Profile and Mechanisms of Cardiovascular Protective Effects of Statins: An Update |
| title_sort | pharmacological profile and mechanisms of cardiovascular protective effects of statins an update |
| topic | cardiovascular protective effects personalized treatment of statins statin kinetics statin side effects statins |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809043 |
| work_keys_str_mv | AT abdallasalemelhwuegi pharmacologicalprofileandmechanismsofcardiovascularprotectiveeffectsofstatinsanupdate AT mustafamelfakhri pharmacologicalprofileandmechanismsofcardiovascularprotectiveeffectsofstatinsanupdate |