Expression Profiles Of PTEN And POGZ Genes In Patients With Autism
Aim: Autism spectrum disorder (ASD), a group of heterogeneous neurodevelopmental disorders, is characterized by complex behavioral phenotypes. Despite extensive studies over many years, the causes of ASD are still unknown. PTEN and POGZ genes are studied as candidate genes that may be responsible fo...
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| Format: | Article |
| Language: | English |
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Alanya Alaaddin Keykubat University
2022-12-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2555703 |
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| author | Didem Öztop Zuhal Hamurcu Nilfer Şahin Esra Demirci Tuğba Tezcan Elif Funda Şener |
| author_facet | Didem Öztop Zuhal Hamurcu Nilfer Şahin Esra Demirci Tuğba Tezcan Elif Funda Şener |
| author_sort | Didem Öztop |
| collection | DOAJ |
| description | Aim: Autism spectrum disorder (ASD), a group of heterogeneous neurodevelopmental disorders, is characterized by complex behavioral phenotypes. Despite extensive studies over many years, the causes of ASD are still unknown. PTEN and POGZ genes are studied as candidate genes that may be responsible for the ASD phenotype. We aimed to investigate the expression levels of PTEN and POGZ genes in autistic patients.Methods: Gene expressions of PTEN and POGZ were investigated in 50 ASD patients and 50 age and gender matched healthy controls. This study was conducted in the Erciyes University Genome and Stem Cell Center (GENKOK).Results: POGZ gene expression was increased in patients compared to controls. According to gender, the expression results of the autistic male patients were significant. PTEN mRNA expression was not statistically significant but found to be lower in patients than in controls. The relationship between the expression of these genes and cognitive deficits was not significant.Conclusion: We recommend investigating other possible candidate genes in larger cohorts and comparing the results with different additional cilinical findings in ASD. |
| format | Article |
| id | doaj-art-6955c4e6efcc41239b483b40e7af28dd |
| institution | OA Journals |
| issn | 2587-0319 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj-art-6955c4e6efcc41239b483b40e7af28dd2025-08-20T02:19:26ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192022-12-016325025510.30565/medalanya.1148353727Expression Profiles Of PTEN And POGZ Genes In Patients With AutismDidem Öztop0https://orcid.org/0000-0003-3189-2112Zuhal Hamurcu1https://orcid.org/0000-0002-0711-4014Nilfer Şahin2https://orcid.org/0000-0001-7120-1561Esra Demirci3https://orcid.org/0000-0002-8424-4947Tuğba Tezcan4https://orcid.org/0000-0003-2216-4084Elif Funda Şener5https://orcid.org/0000-0002-5644-5442ANKARA ÜNİVERSİTESİ, ANKARA TIP FAKÜLTESİERCIYES UNIVERSITY, SCHOOL OF MEDICINEMUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINEERCIYES UNIVERSITY, SCHOOL OF MEDICINEKAPADOKYA VOCATIONAL SCHOOL, KAPADOKYA VOCATIONAL SCHOOLErciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim DalıAim: Autism spectrum disorder (ASD), a group of heterogeneous neurodevelopmental disorders, is characterized by complex behavioral phenotypes. Despite extensive studies over many years, the causes of ASD are still unknown. PTEN and POGZ genes are studied as candidate genes that may be responsible for the ASD phenotype. We aimed to investigate the expression levels of PTEN and POGZ genes in autistic patients.Methods: Gene expressions of PTEN and POGZ were investigated in 50 ASD patients and 50 age and gender matched healthy controls. This study was conducted in the Erciyes University Genome and Stem Cell Center (GENKOK).Results: POGZ gene expression was increased in patients compared to controls. According to gender, the expression results of the autistic male patients were significant. PTEN mRNA expression was not statistically significant but found to be lower in patients than in controls. The relationship between the expression of these genes and cognitive deficits was not significant.Conclusion: We recommend investigating other possible candidate genes in larger cohorts and comparing the results with different additional cilinical findings in ASD.https://dergipark.org.tr/tr/download/article-file/2555703otizmotizm spektrum bozukluklarıptenpogzekspresyonautismautism spectrum disordersptenpogzexpression |
| spellingShingle | Didem Öztop Zuhal Hamurcu Nilfer Şahin Esra Demirci Tuğba Tezcan Elif Funda Şener Expression Profiles Of PTEN And POGZ Genes In Patients With Autism Acta Medica Alanya otizm otizm spektrum bozuklukları pten pogz ekspresyon autism autism spectrum disorders pten pogz expression |
| title | Expression Profiles Of PTEN And POGZ Genes In Patients With Autism |
| title_full | Expression Profiles Of PTEN And POGZ Genes In Patients With Autism |
| title_fullStr | Expression Profiles Of PTEN And POGZ Genes In Patients With Autism |
| title_full_unstemmed | Expression Profiles Of PTEN And POGZ Genes In Patients With Autism |
| title_short | Expression Profiles Of PTEN And POGZ Genes In Patients With Autism |
| title_sort | expression profiles of pten and pogz genes in patients with autism |
| topic | otizm otizm spektrum bozuklukları pten pogz ekspresyon autism autism spectrum disorders pten pogz expression |
| url | https://dergipark.org.tr/tr/download/article-file/2555703 |
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