Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer

Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer

BackgroundRecent studies have increasingly reported abnormal glutathione (GSH) metabolism within the tumor microenvironment across various solid tumors. However, the specific mechanisms underlying aberrant GSH metabolism in pancreatic cancer (PC) remain unclear. This study aims to investigate the pr...

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Bibliographic Details
Main Authors: Xinya Jia, Qiang Zhang, Zhe Wang, Jianliang Cao, Anran Song, Chao Lan, Yuepeng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
single-cell RNA sequencing
bulk RNA sequencing
GSH metabolism
GSTA4 gene
pancreatic cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571431/full
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