The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation
INTRODUCTION: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options. OBJECTIVE: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia (SBD)
2025-04-01
|
| Series: | Surgical & Cosmetic Dermatology |
| Subjects: | |
| Online Access: | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250350.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849730324857094144 |
|---|---|
| author | Olena Baliuk Oleh Akimov Elena Vazhnichaya Vitalii Kostenko Ivan Starchenko |
| author_facet | Olena Baliuk Oleh Akimov Elena Vazhnichaya Vitalii Kostenko Ivan Starchenko |
| author_sort | Olena Baliuk |
| collection | DOAJ |
| description | INTRODUCTION: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options.
OBJECTIVE: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on hair regrowth and biochemical and histological skin parameters in animals following chemical depilation.
METHODS: Experiments were conducted on 50 adult male Wistar rats. Alopecia was induced using a commercial depilatory product containing potassium thioglycolate. A 5% EMHPS gel (125 mg/kg) was applied daily to the depilated skin. Trichoscopy, biochemical analysis, and histological examination of skin samples were performed on days 3, 9, and 21 of treatment.
RESULTS: The EMHPS gel demonstrated a tendency to accelerate hair regrowth, reduce lipid peroxidation, normalize antioxidant enzyme activity, and restore hydroxyproline and glycosaminoglycan levels in the treated skin compared to the untreated pathology control.
CONCLUSIONS: The EMHPS gel primarily influences skin biochemical parameters and may be beneficial for treating forms of alopecia associated with oxidative stress. |
| format | Article |
| id | doaj-art-6954bea1397240cd910fb61bf21d7484 |
| institution | DOAJ |
| issn | 1984-8773 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Brasileira de Dermatologia (SBD) |
| record_format | Article |
| series | Surgical & Cosmetic Dermatology |
| spelling | doaj-art-6954bea1397240cd910fb61bf21d74842025-08-20T03:08:55ZengSociedade Brasileira de Dermatologia (SBD)Surgical & Cosmetic Dermatology1984-87732025-04-011710.5935/scd1984-8773.2025170350The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilationOlena Baliuk0Oleh Akimov1Elena Vazhnichaya2Vitalii Kostenko3Ivan Starchenko4Poltava State Medical University, Departamento de Farmacologia, Poltava - Poltava, UcrâniaPoltava State Medical University, Departamento de Fisiopatologia, Poltava - Poltava, UcrâniaPoltava State Medical University, Departamento de Farmacologia, Poltava - Poltava, UcrâniaPoltava State Medical University, Departamento de Fisiopatologia, Poltava - Poltava, UcrâniaPoltava State Medical University, Departamento de Anatomia Patológica e Medicina Forense, Poltava - Poltava, UcrâniaINTRODUCTION: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options. OBJECTIVE: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on hair regrowth and biochemical and histological skin parameters in animals following chemical depilation. METHODS: Experiments were conducted on 50 adult male Wistar rats. Alopecia was induced using a commercial depilatory product containing potassium thioglycolate. A 5% EMHPS gel (125 mg/kg) was applied daily to the depilated skin. Trichoscopy, biochemical analysis, and histological examination of skin samples were performed on days 3, 9, and 21 of treatment. RESULTS: The EMHPS gel demonstrated a tendency to accelerate hair regrowth, reduce lipid peroxidation, normalize antioxidant enzyme activity, and restore hydroxyproline and glycosaminoglycan levels in the treated skin compared to the untreated pathology control. CONCLUSIONS: The EMHPS gel primarily influences skin biochemical parameters and may be beneficial for treating forms of alopecia associated with oxidative stress.http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250350.pdfhairhair removalskin |
| spellingShingle | Olena Baliuk Oleh Akimov Elena Vazhnichaya Vitalii Kostenko Ivan Starchenko The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation Surgical & Cosmetic Dermatology hair hair removal skin |
| title | The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation |
| title_full | The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation |
| title_fullStr | The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation |
| title_full_unstemmed | The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation |
| title_short | The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation |
| title_sort | influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation |
| topic | hair hair removal skin |
| url | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250350.pdf |
| work_keys_str_mv | AT olenabaliuk theinfluenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT olehakimov theinfluenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT elenavazhnichaya theinfluenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT vitaliikostenko theinfluenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT ivanstarchenko theinfluenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT olenabaliuk influenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT olehakimov influenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT elenavazhnichaya influenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT vitaliikostenko influenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation AT ivanstarchenko influenceoftopicalantioxidantuseonhairregrowthandskinconditionafterchemicaldepilation |