The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation
INTRODUCTION: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options. OBJECTIVE: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia (SBD)
2025-04-01
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| Series: | Surgical & Cosmetic Dermatology |
| Subjects: | |
| Online Access: | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250350.pdf |
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| Summary: | INTRODUCTION: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options.
OBJECTIVE: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on hair regrowth and biochemical and histological skin parameters in animals following chemical depilation.
METHODS: Experiments were conducted on 50 adult male Wistar rats. Alopecia was induced using a commercial depilatory product containing potassium thioglycolate. A 5% EMHPS gel (125 mg/kg) was applied daily to the depilated skin. Trichoscopy, biochemical analysis, and histological examination of skin samples were performed on days 3, 9, and 21 of treatment.
RESULTS: The EMHPS gel demonstrated a tendency to accelerate hair regrowth, reduce lipid peroxidation, normalize antioxidant enzyme activity, and restore hydroxyproline and glycosaminoglycan levels in the treated skin compared to the untreated pathology control.
CONCLUSIONS: The EMHPS gel primarily influences skin biochemical parameters and may be beneficial for treating forms of alopecia associated with oxidative stress. |
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| ISSN: | 1984-8773 |