The primary somatosensory sensory cortex-basolateral amygdala pathway contributes to comorbid depression in spared nerve injury-induced neuropathic pain

The primary somatosensory sensory cortex-basolateral amygdala pathway contributes to comorbid depression in spared nerve injury-induced neuropathic pain

Abstract Comorbid depression in chronic pain is a prevalent health problem, yet the underlying neural mechanisms remain largely unexplored. This study identified a dedicated neural circuit connecting the hind limb region of the primary somatosensory cortex (S1HL) to the basolateral amygdala (BLA) th...

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Bibliographic Details
Main Authors: Guo Chen, Min Luo, Wentao Chen, Yu Zhang, Zuchao Gu, Miaomiao Xu, Ying Zhang, Jiang Bian
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Chronic pain
Depression
Primary somatosensory cortex
Basolateral amygdala
Cholecystokinin
Online Access:https://doi.org/10.1038/s41598-025-97164-3
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