Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma
Abstract Neddylation, as a type of post-translational modification, plays a key role in cancer development. However, the biological characteristics and clinical prognosis value of Neddylation-related genes (NRGs) signatures in clear cell renal cell carcinoma (ccRCC) remain undetermined. Here, we ide...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-05-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02547-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850269149465411584 |
|---|---|
| author | Shengren Cen Yingpeng Li Xinhao Xiong Zihong Ma Yongsheng Wang Xingcheng Gao |
| author_facet | Shengren Cen Yingpeng Li Xinhao Xiong Zihong Ma Yongsheng Wang Xingcheng Gao |
| author_sort | Shengren Cen |
| collection | DOAJ |
| description | Abstract Neddylation, as a type of post-translational modification, plays a key role in cancer development. However, the biological characteristics and clinical prognosis value of Neddylation-related genes (NRGs) signatures in clear cell renal cell carcinoma (ccRCC) remain undetermined. Here, we identified two subtypes of NRGs in ccRCC based on TCGA data and constructed a NRGs risk signature (NRGS). Survival analysis, ROC curves, and nomograms showed that NRGS was an important predictor of prognosis in patients with clear cell renal cell carcinoma. We further revealed important correlations between NRGS and clinicopathological features, gene mutations, drug sensitivity, and immune cell infiltration. High NRGS indicates a poorer prognosis for kidney cancer, but higher remission rates with immunotherapy. Drug sensitivity also varies across risk groups. UBB was identified as a hub gene for NRGS and was downregulated in ccRCC, which is associated with poor prognosis. In conclusion, this study provides strategies for predicting prognosis and individualizing treatment for ccRCC. |
| format | Article |
| id | doaj-art-69426b3fc98a4a1389b83e5feee73d51 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-69426b3fc98a4a1389b83e5feee73d512025-08-20T01:53:14ZengSpringerDiscover Oncology2730-60112025-05-0116111710.1007/s12672-025-02547-7Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinomaShengren Cen0Yingpeng Li1Xinhao Xiong2Zihong Ma3Yongsheng Wang4Xingcheng Gao5Guangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical UniversityAbstract Neddylation, as a type of post-translational modification, plays a key role in cancer development. However, the biological characteristics and clinical prognosis value of Neddylation-related genes (NRGs) signatures in clear cell renal cell carcinoma (ccRCC) remain undetermined. Here, we identified two subtypes of NRGs in ccRCC based on TCGA data and constructed a NRGs risk signature (NRGS). Survival analysis, ROC curves, and nomograms showed that NRGS was an important predictor of prognosis in patients with clear cell renal cell carcinoma. We further revealed important correlations between NRGS and clinicopathological features, gene mutations, drug sensitivity, and immune cell infiltration. High NRGS indicates a poorer prognosis for kidney cancer, but higher remission rates with immunotherapy. Drug sensitivity also varies across risk groups. UBB was identified as a hub gene for NRGS and was downregulated in ccRCC, which is associated with poor prognosis. In conclusion, this study provides strategies for predicting prognosis and individualizing treatment for ccRCC.https://doi.org/10.1007/s12672-025-02547-7Clear cell renal cell carcinomaNeddylationImmune environmentDrug sensitivityPrognosisUBB |
| spellingShingle | Shengren Cen Yingpeng Li Xinhao Xiong Zihong Ma Yongsheng Wang Xingcheng Gao Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma Discover Oncology Clear cell renal cell carcinoma Neddylation Immune environment Drug sensitivity Prognosis UBB |
| title | Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma |
| title_full | Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma |
| title_fullStr | Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma |
| title_full_unstemmed | Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma |
| title_short | Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma |
| title_sort | comprehensive analysis neddylation related genes identified ubb as a prognostic biomarker for clear cell renal cell carcinoma |
| topic | Clear cell renal cell carcinoma Neddylation Immune environment Drug sensitivity Prognosis UBB |
| url | https://doi.org/10.1007/s12672-025-02547-7 |
| work_keys_str_mv | AT shengrencen comprehensiveanalysisneddylationrelatedgenesidentifiedubbasaprognosticbiomarkerforclearcellrenalcellcarcinoma AT yingpengli comprehensiveanalysisneddylationrelatedgenesidentifiedubbasaprognosticbiomarkerforclearcellrenalcellcarcinoma AT xinhaoxiong comprehensiveanalysisneddylationrelatedgenesidentifiedubbasaprognosticbiomarkerforclearcellrenalcellcarcinoma AT zihongma comprehensiveanalysisneddylationrelatedgenesidentifiedubbasaprognosticbiomarkerforclearcellrenalcellcarcinoma AT yongshengwang comprehensiveanalysisneddylationrelatedgenesidentifiedubbasaprognosticbiomarkerforclearcellrenalcellcarcinoma AT xingchenggao comprehensiveanalysisneddylationrelatedgenesidentifiedubbasaprognosticbiomarkerforclearcellrenalcellcarcinoma |