S100 Protein Family in Lung Cancer: an Updated Narrative Review
Ting Wang, Rui Liu Department of Respiratory Medicine, Xi’an People’s Hospital (Xi’an No.4 hospital), Xi’an, 710004, People’s Republic of ChinaCorrespondence: Rui Liu, Department of Respiratory, Xi’an People’s Hospital (Xi’an No.4 hospital), No. 21 Jiefang Road, Xi’an City, Shaanxi Province, 710004,...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-03-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/s100-protein-family-in-lung-cancer-an-updated-narrative-review-peer-reviewed-fulltext-article-CMAR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850047485238575104 |
|---|---|
| author | Wang T Liu R |
| author_facet | Wang T Liu R |
| author_sort | Wang T |
| collection | DOAJ |
| description | Ting Wang, Rui Liu Department of Respiratory Medicine, Xi’an People’s Hospital (Xi’an No.4 hospital), Xi’an, 710004, People’s Republic of ChinaCorrespondence: Rui Liu, Department of Respiratory, Xi’an People’s Hospital (Xi’an No.4 hospital), No. 21 Jiefang Road, Xi’an City, Shaanxi Province, 710004, People’s Republic of China, Tel/Fax +86-18966721169, Email mafada@126.comAbstract: The S100 protein family comprises 25 known members that modulate variously basic biological behaviors of cells by binding Ca2+ and activating Ca2+-signaling pathways. As the primary cause of cancer-related death, lung cancer is closely associated with several S100 proteins, like S100A2, S100A4, S100A6, S100A8/9, etc. Notably, the functions and mechanisms of different S100 proteins vary in every sub-type of lung cancer. Overall speaking, the abnormal expression of S100 proteins is predominantly observed in lung adenocarcinoma, while their roles are limited in small-cell lung cancer. This review, which presents an update on our previously published review of S100 proteins in lung cancer (2021), aims to enable readers having a deeper understanding of the roles of different S100 proteins in three main sub-types of lung cancer, as well as to facilitate their future researches. It focuses on relevant studies examining the functions of S100 proteins in lung adenocarcinoma, squamous carcinoma, and small-cell lung cancer. This review was conducted based on this standard, and provides a comprehensive evaluation of the literature review on S100 proteins as well as enhances understanding of the relationship between S100 proteins and every sub-type of lung cancer from a new perspective.Keywords: S100 protein family, lung cancer, adenocarcinoma, squamous carcinoma, small cell lung cancer |
| format | Article |
| id | doaj-art-6941291e9dad43a4bf31a3d6e137df97 |
| institution | DOAJ |
| issn | 1179-1322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj-art-6941291e9dad43a4bf31a3d6e137df972025-08-20T02:54:12ZengDove Medical PressCancer Management and Research1179-13222025-03-01Volume 17713722101550S100 Protein Family in Lung Cancer: an Updated Narrative ReviewWang TLiu RTing Wang, Rui Liu Department of Respiratory Medicine, Xi’an People’s Hospital (Xi’an No.4 hospital), Xi’an, 710004, People’s Republic of ChinaCorrespondence: Rui Liu, Department of Respiratory, Xi’an People’s Hospital (Xi’an No.4 hospital), No. 21 Jiefang Road, Xi’an City, Shaanxi Province, 710004, People’s Republic of China, Tel/Fax +86-18966721169, Email mafada@126.comAbstract: The S100 protein family comprises 25 known members that modulate variously basic biological behaviors of cells by binding Ca2+ and activating Ca2+-signaling pathways. As the primary cause of cancer-related death, lung cancer is closely associated with several S100 proteins, like S100A2, S100A4, S100A6, S100A8/9, etc. Notably, the functions and mechanisms of different S100 proteins vary in every sub-type of lung cancer. Overall speaking, the abnormal expression of S100 proteins is predominantly observed in lung adenocarcinoma, while their roles are limited in small-cell lung cancer. This review, which presents an update on our previously published review of S100 proteins in lung cancer (2021), aims to enable readers having a deeper understanding of the roles of different S100 proteins in three main sub-types of lung cancer, as well as to facilitate their future researches. It focuses on relevant studies examining the functions of S100 proteins in lung adenocarcinoma, squamous carcinoma, and small-cell lung cancer. This review was conducted based on this standard, and provides a comprehensive evaluation of the literature review on S100 proteins as well as enhances understanding of the relationship between S100 proteins and every sub-type of lung cancer from a new perspective.Keywords: S100 protein family, lung cancer, adenocarcinoma, squamous carcinoma, small cell lung cancerhttps://www.dovepress.com/s100-protein-family-in-lung-cancer-an-updated-narrative-review-peer-reviewed-fulltext-article-CMARs100 protein familylung canceradenocarcinomasquamous carcinomasmall cell lung cancer |
| spellingShingle | Wang T Liu R S100 Protein Family in Lung Cancer: an Updated Narrative Review Cancer Management and Research s100 protein family lung cancer adenocarcinoma squamous carcinoma small cell lung cancer |
| title | S100 Protein Family in Lung Cancer: an Updated Narrative Review |
| title_full | S100 Protein Family in Lung Cancer: an Updated Narrative Review |
| title_fullStr | S100 Protein Family in Lung Cancer: an Updated Narrative Review |
| title_full_unstemmed | S100 Protein Family in Lung Cancer: an Updated Narrative Review |
| title_short | S100 Protein Family in Lung Cancer: an Updated Narrative Review |
| title_sort | s100 protein family in lung cancer an updated narrative review |
| topic | s100 protein family lung cancer adenocarcinoma squamous carcinoma small cell lung cancer |
| url | https://www.dovepress.com/s100-protein-family-in-lung-cancer-an-updated-narrative-review-peer-reviewed-fulltext-article-CMAR |
| work_keys_str_mv | AT wangt s100proteinfamilyinlungcanceranupdatednarrativereview AT liur s100proteinfamilyinlungcanceranupdatednarrativereview |