Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients
Objectives: This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in a cohort of cervical cancer (CC) patients evaluating its prognostic significance. Methods: All patients diagnosed at Brazilian National Cancer Institute (INCA),...
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| Format: | Article |
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Thieme Revinter Publicações Ltda.
2022-10-01
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| Series: | Brazilian Journal of Oncology |
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| Online Access: | https://www.brazilianjournalofoncology.com.br/details/193/en-US/prevalence-and-prognostic-value-of-the-programmed-cell-death-ligand-1--pd-l1--expression-among-tumor-samples-from-cervical-cancer-patients |
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| author | Michelle Marques Lessa Andreia C. Melo Eduardo Paulino Thais dos Santos Rocha Abreu Carlos Gil Ferreira Luiz Claudio Santos Thuler |
| author_facet | Michelle Marques Lessa Andreia C. Melo Eduardo Paulino Thais dos Santos Rocha Abreu Carlos Gil Ferreira Luiz Claudio Santos Thuler |
| author_sort | Michelle Marques Lessa |
| collection | DOAJ |
| description | Objectives: This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in a cohort of cervical cancer (CC) patients evaluating its prognostic significance.
Methods: All patients diagnosed at Brazilian National Cancer Institute (INCA), in 2011, with invasive CC, squamous cell carcinoma (SCC) or adenocarcinoma (ADC) were retrospectively included. Clinical and treatment data were collected and PD-L1 expression was evaluated according to the percentage of viable tumor cells showing staining. The survival analysis was performed using the Kaplan Meier method.
Results: In total, 152 patients (105 SSC and 47 ADC) were included and the mean age was 52.4 years (±14.4). According to the International Federation of Gynecology and Obstetrics (FIGO) 2009, 84.2% had locally advanced disease (IB2-IVA). PD-L1 expression was considered positive (=1%) in 53.3% of the cases. After adjustment, the multivariable analysis confirmed that SCC (p=0.026) and tumor size >4cm (p=0.023) were independently associated with PD-L1 expression. There were no significant differences in disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS) comparing the subgroups with distinct PD-L1 expression.
Conclusion: In this cohort, PD-L1 expression was not associated with DFS, DSS and OS. |
| format | Article |
| id | doaj-art-6941135915d04d03bd4e4745c1f63548 |
| institution | OA Journals |
| issn | 2526-8732 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-6941135915d04d03bd4e4745c1f635482025-08-20T02:35:24ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322022-10-01180010.5935/2526-8732.20220313Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patientsMichelle Marques Lessa0Andreia C. Melo1Eduardo Paulino2Thais dos Santos Rocha Abreu3Carlos Gil Ferreira4Luiz Claudio Santos Thuler5https://orcid.org/0000-0003-2550-6537Brazilian National Cancer Institute (INCA), Division of Clinical Research and Technological Development - Rio de Janeiro - Rio de Janeiro - BrazilBrazilian National Cancer Institute (INCA), Division of Clinical Research and Technological Development - Rio de Janeiro - Rio de Janeiro - BrazilBrazilian National Cancer Institute (INCA), Section of Clinical Oncology - Rio de Janeiro - Rio de Janeiro - BrazilBrazilian National Cancer Institute (INCA), Division of Clinical Research and Technological Development - Rio de Janeiro - Rio de Janeiro - BrazilOncoclínicas, Clinical Oncology - Sao Paulo - Sao Paulo - BrazilBrazilian National Cancer Institute (INCA), Division of Clinical Research and Technological Development - Rio de Janeiro - Rio de Janeiro - BrazilObjectives: This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in a cohort of cervical cancer (CC) patients evaluating its prognostic significance. Methods: All patients diagnosed at Brazilian National Cancer Institute (INCA), in 2011, with invasive CC, squamous cell carcinoma (SCC) or adenocarcinoma (ADC) were retrospectively included. Clinical and treatment data were collected and PD-L1 expression was evaluated according to the percentage of viable tumor cells showing staining. The survival analysis was performed using the Kaplan Meier method. Results: In total, 152 patients (105 SSC and 47 ADC) were included and the mean age was 52.4 years (±14.4). According to the International Federation of Gynecology and Obstetrics (FIGO) 2009, 84.2% had locally advanced disease (IB2-IVA). PD-L1 expression was considered positive (=1%) in 53.3% of the cases. After adjustment, the multivariable analysis confirmed that SCC (p=0.026) and tumor size >4cm (p=0.023) were independently associated with PD-L1 expression. There were no significant differences in disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS) comparing the subgroups with distinct PD-L1 expression. Conclusion: In this cohort, PD-L1 expression was not associated with DFS, DSS and OS.https://www.brazilianjournalofoncology.com.br/details/193/en-US/prevalence-and-prognostic-value-of-the-programmed-cell-death-ligand-1--pd-l1--expression-among-tumor-samples-from-cervical-cancer-patientsimmune checkpoint inhibitorsuterine cervical neoplasmssurvival |
| spellingShingle | Michelle Marques Lessa Andreia C. Melo Eduardo Paulino Thais dos Santos Rocha Abreu Carlos Gil Ferreira Luiz Claudio Santos Thuler Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients Brazilian Journal of Oncology immune checkpoint inhibitors uterine cervical neoplasms survival |
| title | Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients |
| title_full | Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients |
| title_fullStr | Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients |
| title_full_unstemmed | Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients |
| title_short | Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients |
| title_sort | prevalence and prognostic value of the programmed cell death ligand 1 pd l1 expression among tumor samples from cervical cancer patients |
| topic | immune checkpoint inhibitors uterine cervical neoplasms survival |
| url | https://www.brazilianjournalofoncology.com.br/details/193/en-US/prevalence-and-prognostic-value-of-the-programmed-cell-death-ligand-1--pd-l1--expression-among-tumor-samples-from-cervical-cancer-patients |
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