Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori)
Abstract Background Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and impact on living organisms. However, little is known about their interact...
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2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03120-8 |
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| author | Abrar Muhammad Zhaoyi Qian Yu Li Xiaoyu Lei Junaid Iqbal Xiaoqiang Shen Jintao He Nan Zhang Chao Sun Yongqi Shao |
| author_facet | Abrar Muhammad Zhaoyi Qian Yu Li Xiaoyu Lei Junaid Iqbal Xiaoqiang Shen Jintao He Nan Zhang Chao Sun Yongqi Shao |
| author_sort | Abrar Muhammad |
| collection | DOAJ |
| description | Abstract Background Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and impact on living organisms. However, little is known about their interactions in terrestrial ecosystems. This study investigates the adsorption of Fenpropathrin (FPP) onto two different sizes of polystyrene NMPs and examines their impacts on an insect model, silkworm Bombyx mori. We analyzed the systemic effects of acute exposure to NMPs and FPP, individually and combined, at organismal, tissue, cellular, and gut microbiome levels. Results Our results showed that NMPs can adsorb FPP, with smaller particles having higher adsorption capacity, leading to size-dependent increases in the bioaccumulation and toxicity of FPP. These effects led to higher mortality, reduced body weight, delayed development, and decreased cocoon production in silkworms. Additionally, the pollutants caused physical and oxidative damage to the midgut and altered gene expression related to juvenile hormone (JH) and silk protein synthesis. The gut microbiome analysis revealed significant changes and reduced abundance of potentially beneficial bacteria. Thus, the aggravated toxicity induced by NMPs was size-dependent, with smaller particles (NPs) having a greater impact. Conclusions This study demonstrates the role of NMPs as carriers for contaminants, increasing their bioavailability and toxicity in terrestrial ecosystems. These findings have significant implications for ecosystem health and biodiversity. |
| format | Article |
| id | doaj-art-694021907f604751a71faab1e4e9957b |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-694021907f604751a71faab1e4e9957b2025-01-26T12:50:50ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112010.1186/s12951-025-03120-8Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori)Abrar Muhammad0Zhaoyi Qian1Yu Li2Xiaoyu Lei3Junaid Iqbal4Xiaoqiang Shen5Jintao He6Nan Zhang7Chao Sun8Yongqi Shao9Max Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityAnalysis Center of Agrobiology and Environmental Sciences, Zhejiang UniversityMax Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang UniversityAbstract Background Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and impact on living organisms. However, little is known about their interactions in terrestrial ecosystems. This study investigates the adsorption of Fenpropathrin (FPP) onto two different sizes of polystyrene NMPs and examines their impacts on an insect model, silkworm Bombyx mori. We analyzed the systemic effects of acute exposure to NMPs and FPP, individually and combined, at organismal, tissue, cellular, and gut microbiome levels. Results Our results showed that NMPs can adsorb FPP, with smaller particles having higher adsorption capacity, leading to size-dependent increases in the bioaccumulation and toxicity of FPP. These effects led to higher mortality, reduced body weight, delayed development, and decreased cocoon production in silkworms. Additionally, the pollutants caused physical and oxidative damage to the midgut and altered gene expression related to juvenile hormone (JH) and silk protein synthesis. The gut microbiome analysis revealed significant changes and reduced abundance of potentially beneficial bacteria. Thus, the aggravated toxicity induced by NMPs was size-dependent, with smaller particles (NPs) having a greater impact. Conclusions This study demonstrates the role of NMPs as carriers for contaminants, increasing their bioavailability and toxicity in terrestrial ecosystems. These findings have significant implications for ecosystem health and biodiversity.https://doi.org/10.1186/s12951-025-03120-8Nano(micro)plasticsFenpropathrinAdsorptionBioaccumulationSize-dependent effectsSilkworm |
| spellingShingle | Abrar Muhammad Zhaoyi Qian Yu Li Xiaoyu Lei Junaid Iqbal Xiaoqiang Shen Jintao He Nan Zhang Chao Sun Yongqi Shao Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) Journal of Nanobiotechnology Nano(micro)plastics Fenpropathrin Adsorption Bioaccumulation Size-dependent effects Silkworm |
| title | Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) |
| title_full | Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) |
| title_fullStr | Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) |
| title_full_unstemmed | Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) |
| title_short | Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) |
| title_sort | enhanced bioaccumulation and toxicity of fenpropathrin by polystyrene nano micro plastics in the model insect silkworm bombyx mori |
| topic | Nano(micro)plastics Fenpropathrin Adsorption Bioaccumulation Size-dependent effects Silkworm |
| url | https://doi.org/10.1186/s12951-025-03120-8 |
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