Etomoxir Sodium Salt Promotes Imidazole Ketone Erastin-Induced Myeloid-Derived Suppressor Cell Ferroptosis and Enhances Cancer Therapy

Etomoxir Sodium Salt Promotes Imidazole Ketone Erastin-Induced Myeloid-Derived Suppressor Cell Ferroptosis and Enhances Cancer Therapy

Although ferroptosis inducers trigger ferroptotic tumor cells and immune cells in the tumor microenvironment (TME), imidazole ketone erastin (IKE)’s induction of ferroptosis shows no effect on tumor growth in immunocompetent tumor-bearing mice due to the presence of myeloid-derived suppressor cells...

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Bibliographic Details
Main Authors:	Nada Mohamady Farouk Abdalsalam, Zihao Liang, Hafiza Kashaf Tariq, Abdulrahman Ibrahim, Rong Li, Xiaochun Wan, Dehong Yan
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Biology
Subjects:	etomoxir sodium salt imidazole ketone erastin myeloid-derived suppressor cell ferroptosis cancer therapy
Online Access:	https://www.mdpi.com/2079-7737/13/11/949
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