The role of macrophage metabolic reprogramming in myocardial infarction
Myocardial infarction (MI) is one of the major cardiovascular diseases that threaten human health and the post-MI inflammation affects its progression and prognosis. Although the inflammatory response is necessary for tissue repair, persistent inflammatory activation exacerbates the process of cardi...
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| Format: | Article |
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Editorial Office of Journal of Guangxi Medical University
2024-11-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.004 |
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| author | ZOU Zicong GU Muyang CHENG Xiang |
| author_facet | ZOU Zicong GU Muyang CHENG Xiang |
| author_sort | ZOU Zicong |
| collection | DOAJ |
| description | Myocardial infarction (MI) is one of the major cardiovascular diseases that threaten human health and the post-MI inflammation affects its progression and prognosis. Although the inflammatory response is necessary for tissue repair, persistent inflammatory activation exacerbates the process of cardiac remodeling and serves as an important factor of heart failure after MI. Macrophages, as one of the important innate immune cells, play a crucial role in the immune response, necrotic tissue clearance, and tissue repair after MI. While adapting to the post-MI microenvironment, responding to activation signals, and exerting functions, the metabolic phenotype of macrophages undergo significant changes. The metabolic reprogramming mechanism of macrophages in response to microenvironmental changes after MI is also the basis for their phenotypic and functional plasticity, allowing them to play different roles at various stages after MI. This review summarizes the phenomenon of metabolic reprogramming in macrophages after MI and its impact on the regulation of inflammation and tissue repair after MI, providing more perspectives and scientific evidence for the development of macrophage-targeted therapeutic strategies. |
| format | Article |
| id | doaj-art-693a5b5e093844b8a7cf1c15c7bfa3e1 |
| institution | Kabale University |
| issn | 1005-930X |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-693a5b5e093844b8a7cf1c15c7bfa3e12025-08-20T03:52:48ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-11-0141111470147610.16190/j.cnki.45-1211/r.2024.11.004gxykdxxb-41-11-1470The role of macrophage metabolic reprogramming in myocardial infarctionZOU Zicong0GU Muyang1CHENG Xiang2Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaMyocardial infarction (MI) is one of the major cardiovascular diseases that threaten human health and the post-MI inflammation affects its progression and prognosis. Although the inflammatory response is necessary for tissue repair, persistent inflammatory activation exacerbates the process of cardiac remodeling and serves as an important factor of heart failure after MI. Macrophages, as one of the important innate immune cells, play a crucial role in the immune response, necrotic tissue clearance, and tissue repair after MI. While adapting to the post-MI microenvironment, responding to activation signals, and exerting functions, the metabolic phenotype of macrophages undergo significant changes. The metabolic reprogramming mechanism of macrophages in response to microenvironmental changes after MI is also the basis for their phenotypic and functional plasticity, allowing them to play different roles at various stages after MI. This review summarizes the phenomenon of metabolic reprogramming in macrophages after MI and its impact on the regulation of inflammation and tissue repair after MI, providing more perspectives and scientific evidence for the development of macrophage-targeted therapeutic strategies.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.004myocardial infarctionmacrophagesmetabolic reprogramminginflammation |
| spellingShingle | ZOU Zicong GU Muyang CHENG Xiang The role of macrophage metabolic reprogramming in myocardial infarction Guangxi Yike Daxue xuebao myocardial infarction macrophages metabolic reprogramming inflammation |
| title | The role of macrophage metabolic reprogramming in myocardial infarction |
| title_full | The role of macrophage metabolic reprogramming in myocardial infarction |
| title_fullStr | The role of macrophage metabolic reprogramming in myocardial infarction |
| title_full_unstemmed | The role of macrophage metabolic reprogramming in myocardial infarction |
| title_short | The role of macrophage metabolic reprogramming in myocardial infarction |
| title_sort | role of macrophage metabolic reprogramming in myocardial infarction |
| topic | myocardial infarction macrophages metabolic reprogramming inflammation |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.004 |
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