Evolutionary Pro‐To‐Thr Mutation in the Intrinsically Disordered Domain of ANP32 Family Members Modulates Their Target Binding Modes

Evolutionary Pro‐To‐Thr Mutation in the Intrinsically Disordered Domain of ANP32 Family Members Modulates Their Target Binding Modes

Abstract Gene duplication has allowed protein evolution toward novel functions and mechanisms. The differences between paralogous genes frequently rely on the sequence of disordered regions. For instance, in mammals, the chaperones ANP32A and ANP32B share a common evolutionary line and have some exc...

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Bibliographic Details
Main Authors: Blanca Baños‐Jaime, Ana B. Uceda‐Mayo, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Alejandro Velázquez‐Cruz, Adrián Velázquez‐Campoy, Laura Corrales‐Guerrero, Miguel A. De la Rosa, Irene Díaz‐Moreno
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cytochrome c
HuR
intrinsically disordered domain
isothermal calorimetry
nuclear magnetic resonance
Online Access:https://doi.org/10.1002/advs.202415566
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