The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages
Background: miRNA 21 exhibits an increased expression in breast cancer (BC). However, its relationship with the 1-year survival of breast cancer patients is still disputable and under serious discussion. Methods: Cohort prospective study involving 49 breast cancer patients was done, comprising 26 in...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-01-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | http://www.actamedindones.org/index.php/ijim/article/view/1886 |
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| author | Pradana Zaky Romadhon Ami Ashariati Prayoga Siprianus Ugroseno Yudho Bintoro Muhammad Noor Diansyah Putu Niken Amrita Merlyna Savitri Choirina Windradi |
| author_facet | Pradana Zaky Romadhon Ami Ashariati Prayoga Siprianus Ugroseno Yudho Bintoro Muhammad Noor Diansyah Putu Niken Amrita Merlyna Savitri Choirina Windradi |
| author_sort | Pradana Zaky Romadhon |
| collection | DOAJ |
| description | Background: miRNA 21 exhibits an increased expression in breast cancer (BC). However, its relationship with the 1-year survival of breast cancer patients is still disputable and under serious discussion. Methods: Cohort prospective study involving 49 breast cancer patients was done, comprising 26 in early stage and 23 in end-stage. We evaluated miRNA-21 values and observed its association with mortality within 1 year. Results: In general, there was a correlation between the increase in miRNA-21 levels and the mortality rate of breast cancer patients (r = 0.651; p <0.05). In the early stages, the increase in miRNA-21 values was not associated with breast cancer mortality (r= 0.25; p=0.218), but in the later stages, we found that the increase in miRNA-21 had a correlation with mortality (r=0.866; p=<0, 05). In advanced stage, high level of miRNA-21 had high asscociation with mortality rate (HR 17,27 95%CI 7,37-40,69). Conclusion: The increase in miRNA-21 values is associated with the 1-year survival of breast cancer patients.
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| format | Article |
| id | doaj-art-6934fa77d62848c884d600de17c817e3 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-6934fa77d62848c884d600de17c817e32025-08-20T03:27:19ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-01-01534The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various StagesPradana Zaky Romadhon0Ami Ashariati Prayoga1Siprianus Ugroseno Yudho Bintoro2Muhammad Noor Diansyah3Putu Niken Amrita4Merlyna Savitri5Choirina Windradi61. Department of Internal Medicine, Airlangga University, Faculty of Medicine, Surabaya, Indonesia 2. Universitas Airlangga Hospital, Surabaya, Indonesia 3. Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia1. Department of Internal Medicine, Airlangga University, Faculty of Medicine, Surabaya, Indonesia 2. Universitas Airlangga Hospital, Surabaya, Indonesia 3. Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia1. Department of Internal Medicine, Airlangga University, Faculty of Medicine, Surabaya, Indonesia 2. Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia1. Department of Internal Medicine, Airlangga University, Faculty of Medicine, Surabaya, Indonesia 2. Universitas Airlangga Hospital, Surabaya, Indonesia 3. Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia1. Department of Internal Medicine, Airlangga University, Faculty of Medicine, Surabaya, Indonesia 2. Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia1. Department of Internal Medicine, Airlangga University, Faculty of Medicine, Surabaya, Indonesia 2. Dr. Soetomo General Teaching Hospital, Surabaya, IndonesiaUniversitas Airlangga Hospital, Surabaya, IndonesiaBackground: miRNA 21 exhibits an increased expression in breast cancer (BC). However, its relationship with the 1-year survival of breast cancer patients is still disputable and under serious discussion. Methods: Cohort prospective study involving 49 breast cancer patients was done, comprising 26 in early stage and 23 in end-stage. We evaluated miRNA-21 values and observed its association with mortality within 1 year. Results: In general, there was a correlation between the increase in miRNA-21 levels and the mortality rate of breast cancer patients (r = 0.651; p <0.05). In the early stages, the increase in miRNA-21 values was not associated with breast cancer mortality (r= 0.25; p=0.218), but in the later stages, we found that the increase in miRNA-21 had a correlation with mortality (r=0.866; p=<0, 05). In advanced stage, high level of miRNA-21 had high asscociation with mortality rate (HR 17,27 95%CI 7,37-40,69). Conclusion: The increase in miRNA-21 values is associated with the 1-year survival of breast cancer patients. http://www.actamedindones.org/index.php/ijim/article/view/1886miRNA-21breast cancermortality ratesurvivalhealth |
| spellingShingle | Pradana Zaky Romadhon Ami Ashariati Prayoga Siprianus Ugroseno Yudho Bintoro Muhammad Noor Diansyah Putu Niken Amrita Merlyna Savitri Choirina Windradi The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages Acta Medica Indonesiana miRNA-21 breast cancer mortality rate survival health |
| title | The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages |
| title_full | The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages |
| title_fullStr | The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages |
| title_full_unstemmed | The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages |
| title_short | The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages |
| title_sort | association between plasma mirna 21 levels with overall 1 year survival rate of breast cancer patients at various stages |
| topic | miRNA-21 breast cancer mortality rate survival health |
| url | http://www.actamedindones.org/index.php/ijim/article/view/1886 |
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