Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.

Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.

Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis. In contrast, little is known regarding the role of th...

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Bibliographic Details
Main Authors: Veronica G Beaudry, Dadi Jiang, Rachel L Dusek, Eunice J Park, Stevan Knezevich, Katie Ridd, Hannes Vogel, Boris C Bastian, Laura D Attardi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001168&type=printable
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