Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child
The present patient was a 4-year-old boy. His hepatitis C virus genotype was 2a, and his viral load was high (1400,000 U/mL). The pretreatment liver biopsy revealed no fibrosis or malignancy and mild chronic hepatitis; his Knodell's histological activity (HAI) score was 4. Single nucleotide pol...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/597348 |
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| author | Takeshi Endo Koichi Ito Tokio Sugiura Kenji Goto |
| author_facet | Takeshi Endo Koichi Ito Tokio Sugiura Kenji Goto |
| author_sort | Takeshi Endo |
| collection | DOAJ |
| description | The present patient was a 4-year-old boy. His hepatitis C virus genotype was 2a, and his viral load was high (1400,000 U/mL). The pretreatment liver biopsy revealed no fibrosis or malignancy and mild chronic hepatitis; his Knodell's histological activity (HAI) score was 4. Single nucleotide polymorphism of IL28B (rs8099917) was major type. The patient began antiviral treatment with pegylated interferon alpha 2a (90 μg/week). At week 9, serum HCV RNA became undetectable, with a sensitivity of 50 copies/mL. Antiviral treatment was discontinued at week 11 because the ALT level increased to 610 U/L. After discontinuation of therapy, the patient’s serum HCV RNA status became positive again. The serum viral load increased to 100,000 U/mL. During this period, he had been observed without medication. Sixteen months after stopping treatment, serum HCV became undetectable. Over a 4-year period, HCV RNA became negative and his anti-HCV antibody titer gradually decreased. In conclusion, though antiviral therapy resulted in failure or incomplete therapy, a reduced viral load resulted in viral clearance in the present patient. Interleukin 28B genotype might have association with the clearance of hepatitis C virus after discontinuation of antiviral therapy. |
| format | Article |
| id | doaj-art-69336db5a57e426881bface42c58e283 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-69336db5a57e426881bface42c58e2832025-02-03T01:20:39ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/597348597348Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a ChildTakeshi Endo0Koichi Ito1Tokio Sugiura2Kenji Goto3Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Nagoya 467-8601, Mizuho-Cho, Mizuho-Ku, JapanDepartment of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Nagoya 467-8601, Mizuho-Cho, Mizuho-Ku, JapanDepartment of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Nagoya 467-8601, Mizuho-Cho, Mizuho-Ku, JapanDepartment of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Nagoya 467-8601, Mizuho-Cho, Mizuho-Ku, JapanThe present patient was a 4-year-old boy. His hepatitis C virus genotype was 2a, and his viral load was high (1400,000 U/mL). The pretreatment liver biopsy revealed no fibrosis or malignancy and mild chronic hepatitis; his Knodell's histological activity (HAI) score was 4. Single nucleotide polymorphism of IL28B (rs8099917) was major type. The patient began antiviral treatment with pegylated interferon alpha 2a (90 μg/week). At week 9, serum HCV RNA became undetectable, with a sensitivity of 50 copies/mL. Antiviral treatment was discontinued at week 11 because the ALT level increased to 610 U/L. After discontinuation of therapy, the patient’s serum HCV RNA status became positive again. The serum viral load increased to 100,000 U/mL. During this period, he had been observed without medication. Sixteen months after stopping treatment, serum HCV became undetectable. Over a 4-year period, HCV RNA became negative and his anti-HCV antibody titer gradually decreased. In conclusion, though antiviral therapy resulted in failure or incomplete therapy, a reduced viral load resulted in viral clearance in the present patient. Interleukin 28B genotype might have association with the clearance of hepatitis C virus after discontinuation of antiviral therapy.http://dx.doi.org/10.1155/2012/597348 |
| spellingShingle | Takeshi Endo Koichi Ito Tokio Sugiura Kenji Goto Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child Case Reports in Medicine |
| title | Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child |
| title_full | Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child |
| title_fullStr | Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child |
| title_full_unstemmed | Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child |
| title_short | Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child |
| title_sort | hepatitis c virus clearance after discontinuation of pegylated interferon alpha 2a monotherapy in a child |
| url | http://dx.doi.org/10.1155/2012/597348 |
| work_keys_str_mv | AT takeshiendo hepatitiscvirusclearanceafterdiscontinuationofpegylatedinterferonalpha2amonotherapyinachild AT koichiito hepatitiscvirusclearanceafterdiscontinuationofpegylatedinterferonalpha2amonotherapyinachild AT tokiosugiura hepatitiscvirusclearanceafterdiscontinuationofpegylatedinterferonalpha2amonotherapyinachild AT kenjigoto hepatitiscvirusclearanceafterdiscontinuationofpegylatedinterferonalpha2amonotherapyinachild |