CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells

BackgroundPolymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) mediate cancer immune suppression by promoting an immunosuppressive microenvironment that inhibits effective anti-tumor immunity. However, they are still a poorly understood, heterogeneous mix of neutrophil subsets. This study...

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Bibliographic Details
Main Authors: Chris D. St. Laurent, Zeinab Jame-Chenarboo, Alyssa E. Beck, Stacey Stubblefield, Shiteng Duan, Darren Sigal, Matthew S. Macauley
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1570121/full
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