CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells

CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells

BackgroundPolymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) mediate cancer immune suppression by promoting an immunosuppressive microenvironment that inhibits effective anti-tumor immunity. However, they are still a poorly understood, heterogeneous mix of neutrophil subsets. This study...

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Bibliographic Details
Main Authors:	Chris D. St. Laurent, Zeinab Jame-Chenarboo, Alyssa E. Beck, Stacey Stubblefield, Shiteng Duan, Darren Sigal, Matthew S. Macauley
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Oncology
Subjects:	Siglec MDSC neutrophil CD16 T cell suppression steady-state
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1570121/full
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