NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic bodies (ApoBDs) to promote dead cell clearance...

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Bibliographic Details
Main Authors: Bo Shi, Caolingzhi Tang, Stephanie F. Rutter, Omar Audi, Dilara C. Ozkocak, Alice M. Trenerry, Daniel S. Simpson, Scott A. Williams, Quan T. Le, Gemma F. Ryan, Ponsuge T. M. Cooray, James E. Vince, Jason M. Mackenzie, Mark D. Hulett, Thanh Kha Phan, Ivan K. H. Poon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
apoptosis
apoptotic bodies
NINJ1
norovirus
inflammation
extracellular vesicles (EVs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1599809/full
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