Prospective association between plasma amino acids and three Multimorbidity patterns in older adults
Abstract The role of metabolomic profiling on different multimorbidity patterns remains unknown. This study aims to assess the prospective relationship between plasma concentrations of amino acids and three different multimorbidity patterns: musculoskeletal and mental multimorbidity, cardiometabolic...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-06683-6 |
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| author | Grace Velapatiño-Gamarra Alberto Lana Humberto Yévenes-Briones Juan Cárdenas-Valladolid José R. Banegas Fernando Rodríguez-Artalejo Esther López-García Francisco Félix Caballero |
| author_facet | Grace Velapatiño-Gamarra Alberto Lana Humberto Yévenes-Briones Juan Cárdenas-Valladolid José R. Banegas Fernando Rodríguez-Artalejo Esther López-García Francisco Félix Caballero |
| author_sort | Grace Velapatiño-Gamarra |
| collection | DOAJ |
| description | Abstract The role of metabolomic profiling on different multimorbidity patterns remains unknown. This study aims to assess the prospective relationship between plasma concentrations of amino acids and three different multimorbidity patterns: musculoskeletal and mental multimorbidity, cardiometabolic multimorbidity, and cardiopulmonary multimorbidity. The study comprised a total of 1488 older adults from the Seniors-ENRICA 2 Spanish cohort. Plasma concentrations of alanine, glutamine, glycine, histidine, branched-chain amino acids, and aromatic amino acids were measured. Generalized estimating equation models were used to assess the prospective association between amino acids and multimorbidity patterns. Higher plasma concentrations of branched-chain amino acids as leucine [Odds Ratio (OR) per 1-SD increment = 1.05, 95% confidence interval (CI) = 1.01–1.08)], isoleucine (OR = 1.05, 95% CI = 1.01–1.08), and valine (OR = 1.04, 95% CI = 1.01–1.08) were related to cardiometabolic multimorbidity, while lower concentrations of glycine (OR = 0.95, 95% CI = 0.91–0.99) and tyrosine (OR = 0.96, 95% CI = 0.93–0.98) were also associated with the same multimorbidity pattern. On the other hand, higher plasma concentrations of glutamine (OR = 1.18, 95% CI = 1.03–1.34) were related to cardiopulmonary multimorbidity. In conclusion, branched-chain amino acids may serve as risk markers of cardiometabolic multimorbidity in older adults. Plasma concentrations of other amino acid species such as glycine, tyrosine, and glutamine could also help to identify cardiometabolic and cardiopulmonary multimorbidity patterns. |
| format | Article |
| id | doaj-art-692e136723cb4daba73ee77077e0c4b6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-692e136723cb4daba73ee77077e0c4b62025-08-20T03:37:30ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-06683-6Prospective association between plasma amino acids and three Multimorbidity patterns in older adultsGrace Velapatiño-Gamarra0Alberto Lana1Humberto Yévenes-Briones2Juan Cárdenas-Valladolid3José R. Banegas4Fernando Rodríguez-Artalejo5Esther López-García6Francisco Félix Caballero7Department of Preventive Medicine and Public Health, Universidad Autónoma de MadridDepartment of Medicine, Universidad de Oviedo/ISPADepartment of Preventive Medicine and Public Health, Universidad Autónoma de MadridDirección General de Investigación y Docencia, Consejería de Sanidad de la Comunidad de MadridDepartment of Preventive Medicine and Public Health, Universidad Autónoma de MadridDepartment of Preventive Medicine and Public Health, Universidad Autónoma de MadridDepartment of Preventive Medicine and Public Health, Universidad Autónoma de MadridDepartment of Preventive Medicine and Public Health, Universidad Autónoma de MadridAbstract The role of metabolomic profiling on different multimorbidity patterns remains unknown. This study aims to assess the prospective relationship between plasma concentrations of amino acids and three different multimorbidity patterns: musculoskeletal and mental multimorbidity, cardiometabolic multimorbidity, and cardiopulmonary multimorbidity. The study comprised a total of 1488 older adults from the Seniors-ENRICA 2 Spanish cohort. Plasma concentrations of alanine, glutamine, glycine, histidine, branched-chain amino acids, and aromatic amino acids were measured. Generalized estimating equation models were used to assess the prospective association between amino acids and multimorbidity patterns. Higher plasma concentrations of branched-chain amino acids as leucine [Odds Ratio (OR) per 1-SD increment = 1.05, 95% confidence interval (CI) = 1.01–1.08)], isoleucine (OR = 1.05, 95% CI = 1.01–1.08), and valine (OR = 1.04, 95% CI = 1.01–1.08) were related to cardiometabolic multimorbidity, while lower concentrations of glycine (OR = 0.95, 95% CI = 0.91–0.99) and tyrosine (OR = 0.96, 95% CI = 0.93–0.98) were also associated with the same multimorbidity pattern. On the other hand, higher plasma concentrations of glutamine (OR = 1.18, 95% CI = 1.03–1.34) were related to cardiopulmonary multimorbidity. In conclusion, branched-chain amino acids may serve as risk markers of cardiometabolic multimorbidity in older adults. Plasma concentrations of other amino acid species such as glycine, tyrosine, and glutamine could also help to identify cardiometabolic and cardiopulmonary multimorbidity patterns.https://doi.org/10.1038/s41598-025-06683-6Amino acidsMusculoskeletal and mental Multimorbidity patternCardiometabolic Multimorbidity patternCardiopulmonary Multimorbidity patternRisk markers |
| spellingShingle | Grace Velapatiño-Gamarra Alberto Lana Humberto Yévenes-Briones Juan Cárdenas-Valladolid José R. Banegas Fernando Rodríguez-Artalejo Esther López-García Francisco Félix Caballero Prospective association between plasma amino acids and three Multimorbidity patterns in older adults Scientific Reports Amino acids Musculoskeletal and mental Multimorbidity pattern Cardiometabolic Multimorbidity pattern Cardiopulmonary Multimorbidity pattern Risk markers |
| title | Prospective association between plasma amino acids and three Multimorbidity patterns in older adults |
| title_full | Prospective association between plasma amino acids and three Multimorbidity patterns in older adults |
| title_fullStr | Prospective association between plasma amino acids and three Multimorbidity patterns in older adults |
| title_full_unstemmed | Prospective association between plasma amino acids and three Multimorbidity patterns in older adults |
| title_short | Prospective association between plasma amino acids and three Multimorbidity patterns in older adults |
| title_sort | prospective association between plasma amino acids and three multimorbidity patterns in older adults |
| topic | Amino acids Musculoskeletal and mental Multimorbidity pattern Cardiometabolic Multimorbidity pattern Cardiopulmonary Multimorbidity pattern Risk markers |
| url | https://doi.org/10.1038/s41598-025-06683-6 |
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