Potential role of 4-hydroxyisoleucine in enhancing fertility in male mice with diet-induced obesity

Potential role of 4-hydroxyisoleucine in enhancing fertility in male mice with diet-induced obesity

BackgroundObesity is associated with hormonal imbalance, increased oxidative stress, and inflammation in the testis. These conditions adversely affect sperm quality, leading to impaired male fertility. Therefore, therapeutic interventions to counteract the adverse effects of obesity are crucial. Thi...

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Bibliographic Details
Main Authors: Emmanuel Osei Nkansah, Yunzhu Lan, Hui Zhang, Binbin Xu, Qiaodan Li, Mohammad Ishraq Zafar, Jian Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
obesity
4-hydroxyisoleucine
4-HIL
male fertility
metabolic disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1561543/full
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