Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.

Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.

The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essentia...

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Bibliographic Details
Main Authors: Lie Li, Claudia E Oropeza, Bruno Sainz, Susan L Uprichard, Frank J Gonzalez, Alan McLachlan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005489&type=printable
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