Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.
The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essentia...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005489&type=printable |
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| _version_ | 1849687110176473088 |
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| author | Lie Li Claudia E Oropeza Bruno Sainz Susan L Uprichard Frank J Gonzalez Alan McLachlan |
| author_facet | Lie Li Claudia E Oropeza Bruno Sainz Susan L Uprichard Frank J Gonzalez Alan McLachlan |
| author_sort | Lie Li |
| collection | DOAJ |
| description | The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4alpha links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability. |
| format | Article |
| id | doaj-art-6924b76b3dbb41ae939f3a500ed063d5 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6924b76b3dbb41ae939f3a500ed063d52025-08-20T03:22:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0145e548910.1371/journal.pone.0005489Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.Lie LiClaudia E OropezaBruno SainzSusan L UprichardFrank J GonzalezAlan McLachlanThe host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4alpha links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005489&type=printable |
| spellingShingle | Lie Li Claudia E Oropeza Bruno Sainz Susan L Uprichard Frank J Gonzalez Alan McLachlan Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. PLoS ONE |
| title | Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. |
| title_full | Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. |
| title_fullStr | Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. |
| title_full_unstemmed | Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. |
| title_short | Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. |
| title_sort | developmental regulation of hepatitis b virus biosynthesis by hepatocyte nuclear factor 4alpha |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005489&type=printable |
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