Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau
ABSTRACT Background Developmental dysplasia of the hip (DDH) is a prevalent pediatric condition with a multifactorial etiology. Its incidence varies geographically, with notably higher rates observed on the Tibet plateau. This study was performed to evaluate the lipidomics signatures associated with...
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Wiley
2025-04-01
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| Online Access: | https://doi.org/10.1002/hcs2.70012 |
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| author | Xiaogang Li Jiamei Ji Ping Li De Yang Nyima Yedron Yanming Lei Tao Chen Jianchu Li Ye Guo Xiao Yang Li Shi Dan Qu |
| author_facet | Xiaogang Li Jiamei Ji Ping Li De Yang Nyima Yedron Yanming Lei Tao Chen Jianchu Li Ye Guo Xiao Yang Li Shi Dan Qu |
| author_sort | Xiaogang Li |
| collection | DOAJ |
| description | ABSTRACT Background Developmental dysplasia of the hip (DDH) is a prevalent pediatric condition with a multifactorial etiology. Its incidence varies geographically, with notably higher rates observed on the Tibet plateau. This study was performed to evaluate the lipidomics signatures associated with DDH by analyzing plasma samples. Methods Fifty infants were recruited, including 25 diagnosed with DDH and 25 age‐matched healthy controls. In addition to plasma samples, comprehensive laboratory test results and medical records were collected for each participant. An untargeted lipidomics profiling approach was employed to identify distinguishing metabolic signatures. Results Lipidomics profiles differed significantly between patients with DDH and healthy controls. Several differential metabolites were identified, including triacylglycerol (TAG)(17:0/18:1/20:1), TAG(17:0/17:0/17:0), phosphatidylethanolamine (PE)(10:0/26:4), TAG(17:0/18:0/18:0), TAG(16:0/17:0/22:1), TAG(16:0/18:0/22:0), TAG(17:0/19:0/19:0), TAG(13:0/20:0/20:0), TAG(18:0/18:0/22:0), and TAG(16:0/20:0/20:0). The primary lipid species showing differences were TAGs and PE. Conclusions Distinct shifts in lipidomics profiles were observed in infants with DDH. To the best of our knowledge, this study is the first to explore lipidomics signatures in patients with DDH. The combined assessment of TAG(17:0/18:1/20:1) and TAG(17:0/17:0/17:0) may serve as a potential diagnostic tool for DDH. |
| format | Article |
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| issn | 2771-1757 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Care Science |
| spelling | doaj-art-691fa7cfd3d44f46a4a3b6328be139ff2025-08-20T02:12:23ZengWileyHealth Care Science2771-17572025-04-014214415310.1002/hcs2.70012Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet PlateauXiaogang Li0Jiamei Ji1Ping Li2De Yang3Nyima Yedron4Yanming Lei5Tao Chen6Jianchu Li7Ye Guo8Xiao Yang9Li Shi10Dan Qu11Biobank Facility, National Infrastructures for Translational Medicine, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaDepartment of Orthopedics People's Hospital of Tibet Autonomous Region Lhasa Tibet ChinaDepartment of Ultrasound People's Hospital of Tibet Autonomous Region Lhasa Tibet ChinaDepartment of Ultrasound People's Hospital of Tibet Autonomous Region Lhasa Tibet ChinaDepartment of Radiology People's Hospital of Tibet Autonomous Region Lhasa Tibet ChinaDepartment of Ultrasound, Beijing Jishuitan Hospital, The 4th Clinical College Peking University Beijing ChinaDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaState Key Laboratory of Complex Severe and Rare Diseases, Department of Clinical Laboratory, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaDepartment of Infectious Diseases People's Hospital of Tibet Autonomous Region Lhasa Tibet ChinaDepartment of Laboratory Medicine People's Hospital of Tibet Autonomous Region Lhasa Tibet ChinaABSTRACT Background Developmental dysplasia of the hip (DDH) is a prevalent pediatric condition with a multifactorial etiology. Its incidence varies geographically, with notably higher rates observed on the Tibet plateau. This study was performed to evaluate the lipidomics signatures associated with DDH by analyzing plasma samples. Methods Fifty infants were recruited, including 25 diagnosed with DDH and 25 age‐matched healthy controls. In addition to plasma samples, comprehensive laboratory test results and medical records were collected for each participant. An untargeted lipidomics profiling approach was employed to identify distinguishing metabolic signatures. Results Lipidomics profiles differed significantly between patients with DDH and healthy controls. Several differential metabolites were identified, including triacylglycerol (TAG)(17:0/18:1/20:1), TAG(17:0/17:0/17:0), phosphatidylethanolamine (PE)(10:0/26:4), TAG(17:0/18:0/18:0), TAG(16:0/17:0/22:1), TAG(16:0/18:0/22:0), TAG(17:0/19:0/19:0), TAG(13:0/20:0/20:0), TAG(18:0/18:0/22:0), and TAG(16:0/20:0/20:0). The primary lipid species showing differences were TAGs and PE. Conclusions Distinct shifts in lipidomics profiles were observed in infants with DDH. To the best of our knowledge, this study is the first to explore lipidomics signatures in patients with DDH. The combined assessment of TAG(17:0/18:1/20:1) and TAG(17:0/17:0/17:0) may serve as a potential diagnostic tool for DDH.https://doi.org/10.1002/hcs2.70012developmental dysplasia of the hipdiagnosislipidomicspediatric orthopedicphosphatidylethanolaminetriacylglycerols |
| spellingShingle | Xiaogang Li Jiamei Ji Ping Li De Yang Nyima Yedron Yanming Lei Tao Chen Jianchu Li Ye Guo Xiao Yang Li Shi Dan Qu Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau Health Care Science developmental dysplasia of the hip diagnosis lipidomics pediatric orthopedic phosphatidylethanolamine triacylglycerols |
| title | Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau |
| title_full | Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau |
| title_fullStr | Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau |
| title_full_unstemmed | Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau |
| title_short | Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau |
| title_sort | plasma lipidomics profiling of developmental dysplasia of the hip in tibet plateau |
| topic | developmental dysplasia of the hip diagnosis lipidomics pediatric orthopedic phosphatidylethanolamine triacylglycerols |
| url | https://doi.org/10.1002/hcs2.70012 |
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