Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand
Abstract The incidence and global spread of dengue are reaching alarming levels. Thailand represents a critical disease epicenter and demands an understanding of the environmental and evolutionary pressures that sustain DENV transmission. Unlike most affected countries experiencing recurrent outbrea...
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Nature Portfolio
2025-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07999-9 |
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| author | Lester J. Perez Julie Yamaguchi Sonja Weiss Christiane Carlos Todd V. Meyer Mary A. Rodgers Pakpoom Phoompoung Yupin Suputtamongkol Gavin A. Cloherty Michael G. Berg |
| author_facet | Lester J. Perez Julie Yamaguchi Sonja Weiss Christiane Carlos Todd V. Meyer Mary A. Rodgers Pakpoom Phoompoung Yupin Suputtamongkol Gavin A. Cloherty Michael G. Berg |
| author_sort | Lester J. Perez |
| collection | DOAJ |
| description | Abstract The incidence and global spread of dengue are reaching alarming levels. Thailand represents a critical disease epicenter and demands an understanding of the environmental and evolutionary pressures that sustain DENV transmission. Unlike most affected countries experiencing recurrent outbreaks of the same serotype or replacement of one serotype for another, Thailand is an ecological niche for all four serotypes. Favorable climate and mosquito vector availability maintain a landscape defined by stable, endemic circulation of genotypes, with minimal genetic variation attributed to sporadic, external introductions. This equilibrium is achieved through inter-serotype competition, characterized by reproductive fitness levels that maintain infections (Re>1) and elevated evolutionary rates ( ~ 10-4), which steadily increase the genetic diversity of each serotype. This conclusion is reinforced by the identification of numerous positively selected mutations, skewed in the direction of non-structural proteins conferring replication and transmission advantages versus those present in structural proteins evading neutralizing antibodies. Precipitous drops in DENV cases following outbreaks of Chikungunya suggest that interactions with other arboviruses also impact DENV dynamics through vector competition, replication inhibition or partial cross-protection. Thailand is a major exporter of DENV cases and novel emergent lineages gaining fitness here are likely to spread internationally. Surveillance is therefore paramount to monitor diversification trends and take measures to avoid the establishment of similar sustained, local transmission in other countries. |
| format | Article |
| id | doaj-art-691a343ac3694ab7a492d8ff2eaa9edf |
| institution | DOAJ |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-691a343ac3694ab7a492d8ff2eaa9edf2025-08-20T03:06:57ZengNature PortfolioCommunications Biology2399-36422025-04-018111510.1038/s42003-025-07999-9Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in ThailandLester J. Perez0Julie Yamaguchi1Sonja Weiss2Christiane Carlos3Todd V. Meyer4Mary A. Rodgers5Pakpoom Phoompoung6Yupin Suputtamongkol7Gavin A. Cloherty8Michael G. Berg9Infectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesFaculty of Medicine, Siriraj Hospital Mahidol UniversityFaculty of Medicine, Siriraj Hospital Mahidol UniversityInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesInfectious Disease Research, Abbott Diagnostics Division, Abbott LaboratoriesAbstract The incidence and global spread of dengue are reaching alarming levels. Thailand represents a critical disease epicenter and demands an understanding of the environmental and evolutionary pressures that sustain DENV transmission. Unlike most affected countries experiencing recurrent outbreaks of the same serotype or replacement of one serotype for another, Thailand is an ecological niche for all four serotypes. Favorable climate and mosquito vector availability maintain a landscape defined by stable, endemic circulation of genotypes, with minimal genetic variation attributed to sporadic, external introductions. This equilibrium is achieved through inter-serotype competition, characterized by reproductive fitness levels that maintain infections (Re>1) and elevated evolutionary rates ( ~ 10-4), which steadily increase the genetic diversity of each serotype. This conclusion is reinforced by the identification of numerous positively selected mutations, skewed in the direction of non-structural proteins conferring replication and transmission advantages versus those present in structural proteins evading neutralizing antibodies. Precipitous drops in DENV cases following outbreaks of Chikungunya suggest that interactions with other arboviruses also impact DENV dynamics through vector competition, replication inhibition or partial cross-protection. Thailand is a major exporter of DENV cases and novel emergent lineages gaining fitness here are likely to spread internationally. Surveillance is therefore paramount to monitor diversification trends and take measures to avoid the establishment of similar sustained, local transmission in other countries.https://doi.org/10.1038/s42003-025-07999-9 |
| spellingShingle | Lester J. Perez Julie Yamaguchi Sonja Weiss Christiane Carlos Todd V. Meyer Mary A. Rodgers Pakpoom Phoompoung Yupin Suputtamongkol Gavin A. Cloherty Michael G. Berg Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand Communications Biology |
| title | Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand |
| title_full | Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand |
| title_fullStr | Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand |
| title_full_unstemmed | Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand |
| title_short | Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand |
| title_sort | climate inter serotype competition and arboviral interactions shape dengue dynamics in thailand |
| url | https://doi.org/10.1038/s42003-025-07999-9 |
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