Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1)
Activated PI3K delta syndrome is a rare primary combined immunodeficiency that can present with lymphoma. Genetic testing of patients with atypical lymphoma may reveal an underlying immunodeficiency and improve clinical outcomes.
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325001043 |
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| author | Alex Wonnaparhown, MD Matthew Farley, MD Holly Miller, DO Charlotte Cunningham-Rundles, MD Catherine Freeman, MBBCh Jacqueline Squire, MD Talal Hilal, MD Allison Rosenthal, DO |
| author_facet | Alex Wonnaparhown, MD Matthew Farley, MD Holly Miller, DO Charlotte Cunningham-Rundles, MD Catherine Freeman, MBBCh Jacqueline Squire, MD Talal Hilal, MD Allison Rosenthal, DO |
| author_sort | Alex Wonnaparhown, MD |
| collection | DOAJ |
| description | Activated PI3K delta syndrome is a rare primary combined immunodeficiency that can present with lymphoma. Genetic testing of patients with atypical lymphoma may reveal an underlying immunodeficiency and improve clinical outcomes. |
| format | Article |
| id | doaj-art-69163d2f902e487db4c83b2a0776b88f |
| institution | DOAJ |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-69163d2f902e487db4c83b2a0776b88f2025-08-20T03:01:41ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-08-014310050310.1016/j.jacig.2025.100503Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1)Alex Wonnaparhown, MD0Matthew Farley, MD1Holly Miller, DO2Charlotte Cunningham-Rundles, MD3Catherine Freeman, MBBCh4Jacqueline Squire, MD5Talal Hilal, MD6Allison Rosenthal, DO7Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Phoenix, Ariz; Corresponding author: Alex Wonnaparhown, MD, 13400 East Shea Boulevard, Scottsdale, AZ 85259.Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Phoenix, ArizCenter for Cancer and Blood Disorders, Phoenix Children's/Mayo Clinic Arizona, Phoenix, ArizDivision of Allergy and Clinical Immunology, Department of Medicine and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NYDivision of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Phoenix, ArizDivision of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Jacksonville, FlaDivision of Hematology and Medical Oncology, Mayo Clinic, Phoenix, ArizDivision of Hematology and Medical Oncology, Mayo Clinic, Phoenix, ArizActivated PI3K delta syndrome is a rare primary combined immunodeficiency that can present with lymphoma. Genetic testing of patients with atypical lymphoma may reveal an underlying immunodeficiency and improve clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2772829325001043Marginal zone lymphomaprimary immunodeficiencyactivated phosphoinositide 3-kinase delta syndromegenomicscase report |
| spellingShingle | Alex Wonnaparhown, MD Matthew Farley, MD Holly Miller, DO Charlotte Cunningham-Rundles, MD Catherine Freeman, MBBCh Jacqueline Squire, MD Talal Hilal, MD Allison Rosenthal, DO Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1) Journal of Allergy and Clinical Immunology: Global Marginal zone lymphoma primary immunodeficiency activated phosphoinositide 3-kinase delta syndrome genomics case report |
| title | Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1) |
| title_full | Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1) |
| title_fullStr | Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1) |
| title_full_unstemmed | Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1) |
| title_short | Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1) |
| title_sort | refractory marginal zone lymphoma uncovers activated phosphoinositide 3 kinase delta syndrome type 1 apds1 |
| topic | Marginal zone lymphoma primary immunodeficiency activated phosphoinositide 3-kinase delta syndrome genomics case report |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325001043 |
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