Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1)

Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1)

Activated PI3K delta syndrome is a rare primary combined immunodeficiency that can present with lymphoma. Genetic testing of patients with atypical lymphoma may reveal an underlying immunodeficiency and improve clinical outcomes.

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Bibliographic Details
Main Authors: Alex Wonnaparhown, MD, Matthew Farley, MD, Holly Miller, DO, Charlotte Cunningham-Rundles, MD, Catherine Freeman, MBBCh, Jacqueline Squire, MD, Talal Hilal, MD, Allison Rosenthal, DO
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
Marginal zone lymphoma
primary immunodeficiency
activated phosphoinositide 3-kinase delta syndrome
genomics
case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829325001043
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Description
Summary:Activated PI3K delta syndrome is a rare primary combined immunodeficiency that can present with lymphoma. Genetic testing of patients with atypical lymphoma may reveal an underlying immunodeficiency and improve clinical outcomes.
ISSN:2772-8293

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