The Treg/Th17 Paradigm in Lung Cancer
Pathogenic mechanisms underlying the development of lung cancer are very complex and not yet entirely clarified. T lymphocytes and their immune-regulatory cytokines play a pivotal role in controlling tumor growth and metastasis. Following activation by unique cytokines, CD4+ T helper cells different...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/730380 |
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| _version_ | 1850120264652685312 |
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| author | Min-Chao Duan Xiao-Ning Zhong Guang-Nan Liu Jin-Ru Wei |
| author_facet | Min-Chao Duan Xiao-Ning Zhong Guang-Nan Liu Jin-Ru Wei |
| author_sort | Min-Chao Duan |
| collection | DOAJ |
| description | Pathogenic mechanisms underlying the development of lung cancer are very complex and not yet entirely clarified. T lymphocytes and their immune-regulatory cytokines play a pivotal role in controlling tumor growth and metastasis. Following activation by unique cytokines, CD4+ T helper cells differentiate into Th1, Th2, Th17, and regulatory T cells (Tregs). Traditionally, research in lung cancer immunity has focused almost exclusively on Th1/Th2 cell balance. Recently, Th17 cells and Tregs represent an intriguing issue to be addressed in lung cancer pathogenesis. Tregs play an important role in the preservation of self-tolerance and modulation of overall immune responses against tumor cells. Th17 cells directly or via other proinflammatory cytokines modulate antitumor immune responses. Notably, there is a close relation between Tregs and Th17 cells. However, the possible interaction between these subsets in lung cancer remains to be elucidated. In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent a useful tool for lung cancer treatment in the future. The purpose of this review is to discuss recent findings of the role of these novel populations in lung cancer immunity and to highlight the pleiotropic effects of these subsets on the development and regulation of lung cancer. |
| format | Article |
| id | doaj-art-6912f9d48cac4ba0b2e46dfc8329b315 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6912f9d48cac4ba0b2e46dfc8329b3152025-08-20T02:35:24ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/730380730380The Treg/Th17 Paradigm in Lung CancerMin-Chao Duan0Xiao-Ning Zhong1Guang-Nan Liu2Jin-Ru Wei3Department of Respiratory Medicine, The Eighth People’s Hospital of Nanning, Nanning, Guangxi 530001, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Respiratory Medicine, The First People’s Hospital of Nanning, Nanning, Guangxi 530022, ChinaPathogenic mechanisms underlying the development of lung cancer are very complex and not yet entirely clarified. T lymphocytes and their immune-regulatory cytokines play a pivotal role in controlling tumor growth and metastasis. Following activation by unique cytokines, CD4+ T helper cells differentiate into Th1, Th2, Th17, and regulatory T cells (Tregs). Traditionally, research in lung cancer immunity has focused almost exclusively on Th1/Th2 cell balance. Recently, Th17 cells and Tregs represent an intriguing issue to be addressed in lung cancer pathogenesis. Tregs play an important role in the preservation of self-tolerance and modulation of overall immune responses against tumor cells. Th17 cells directly or via other proinflammatory cytokines modulate antitumor immune responses. Notably, there is a close relation between Tregs and Th17 cells. However, the possible interaction between these subsets in lung cancer remains to be elucidated. In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent a useful tool for lung cancer treatment in the future. The purpose of this review is to discuss recent findings of the role of these novel populations in lung cancer immunity and to highlight the pleiotropic effects of these subsets on the development and regulation of lung cancer.http://dx.doi.org/10.1155/2014/730380 |
| spellingShingle | Min-Chao Duan Xiao-Ning Zhong Guang-Nan Liu Jin-Ru Wei The Treg/Th17 Paradigm in Lung Cancer Journal of Immunology Research |
| title | The Treg/Th17 Paradigm in Lung Cancer |
| title_full | The Treg/Th17 Paradigm in Lung Cancer |
| title_fullStr | The Treg/Th17 Paradigm in Lung Cancer |
| title_full_unstemmed | The Treg/Th17 Paradigm in Lung Cancer |
| title_short | The Treg/Th17 Paradigm in Lung Cancer |
| title_sort | treg th17 paradigm in lung cancer |
| url | http://dx.doi.org/10.1155/2014/730380 |
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