Nuclear pore complex dysfunction drives TDP-43 pathology in ALS

Nuclear pore complex dysfunction drives TDP-43 pathology in ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and pathological aggregation of TDP-43. While protein misfolding and impaired autophagy are established features, accumulating evidence highlights the nuclear pore complex...

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Bibliographic Details
Main Authors: O. Ramírez-Núñez, S. Rico-Ríos, P. Torres, V. Ayala, A. Fernàndez-Bernal, M. Ceron-Codorniu, P. Andrés-Benito, A. Vinyals, S. Maqsood, I. Ferrer, R. Pamplona, M. Portero-Otin
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725003374
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