Research progress on the neuroinflammation mechanisms in bipolar disorder
Bipolar disorder (BD) is a chronic, recurrent mental illness characterized by extreme fluctuations in mood and state, clinically manifested as recurrent or alternating manic, depressive, and mixed episodes. The pathogenesis is complex and remains unknown, with neuroinflammation considered as a key f...
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2025-01-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
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| Online Access: | https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-1-107.shtml |
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| _version_ | 1850260627593887744 |
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| author | WANG Xiaohong FANG Yiru |
| author_facet | WANG Xiaohong FANG Yiru |
| author_sort | WANG Xiaohong |
| collection | DOAJ |
| description | Bipolar disorder (BD) is a chronic, recurrent mental illness characterized by extreme fluctuations in mood and state, clinically manifested as recurrent or alternating manic, depressive, and mixed episodes. The pathogenesis is complex and remains unknown, with neuroinflammation considered as a key factor in its development. In-depth research not only helps to understand the etiology, but also provides direction for the development of new therapeutic targets. This paper reviews recent studies on neuroinflammation in BD, discusses changes in peripheral and central inflammation and associated biomarkers, explores the underlying mechanisms of pathogenesis, and briefly describes the mechanisms and potential of mood stabilizers and new therapeutic drugs in anti-inflammatory effect, aiming to suggest possible future research directions. |
| format | Article |
| id | doaj-art-690cdfc8692d4ad089e901cb91f64f3f |
| institution | OA Journals |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-690cdfc8692d4ad089e901cb91f64f3f2025-08-20T01:55:35ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152025-01-0145110711210.3969/j.issn.1674-8115.2025.01.0131674-8115（2025）01-0107-06Research progress on the neuroinflammation mechanisms in bipolar disorderWANG Xiaohong0FANG Yiru1Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Psychiatry & Affective Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaBipolar disorder (BD) is a chronic, recurrent mental illness characterized by extreme fluctuations in mood and state, clinically manifested as recurrent or alternating manic, depressive, and mixed episodes. The pathogenesis is complex and remains unknown, with neuroinflammation considered as a key factor in its development. In-depth research not only helps to understand the etiology, but also provides direction for the development of new therapeutic targets. This paper reviews recent studies on neuroinflammation in BD, discusses changes in peripheral and central inflammation and associated biomarkers, explores the underlying mechanisms of pathogenesis, and briefly describes the mechanisms and potential of mood stabilizers and new therapeutic drugs in anti-inflammatory effect, aiming to suggest possible future research directions.https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-1-107.shtmlbipolar disorderneuroglial cellneuroinflammationbiomarker |
| spellingShingle | WANG Xiaohong FANG Yiru Research progress on the neuroinflammation mechanisms in bipolar disorder Shanghai Jiaotong Daxue xuebao. Yixue ban bipolar disorder neuroglial cell neuroinflammation biomarker |
| title | Research progress on the neuroinflammation mechanisms in bipolar disorder |
| title_full | Research progress on the neuroinflammation mechanisms in bipolar disorder |
| title_fullStr | Research progress on the neuroinflammation mechanisms in bipolar disorder |
| title_full_unstemmed | Research progress on the neuroinflammation mechanisms in bipolar disorder |
| title_short | Research progress on the neuroinflammation mechanisms in bipolar disorder |
| title_sort | research progress on the neuroinflammation mechanisms in bipolar disorder |
| topic | bipolar disorder neuroglial cell neuroinflammation biomarker |
| url | https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-1-107.shtml |
| work_keys_str_mv | AT wangxiaohong researchprogressontheneuroinflammationmechanismsinbipolardisorder AT fangyiru researchprogressontheneuroinflammationmechanismsinbipolardisorder |