A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation
Endometriosis, an estrogen-dependent inflammatory disorder prevalent in reproductive-age women, is characterized by the growth of endometrial-like tissue outside the uterine cavity, leading to chronic pain and infertility. Current therapeutic strategies primarily focus on lesion removal and pain all...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425006118 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850106633396420608 |
|---|---|
| author | Wenwen Liu Jie Shen Jiaqi You Tao Wang Pusheng Yang Yaxin Miao Xiaotong Peng Yimin Yu Chengyu Liu Ang Li Jing Sun |
| author_facet | Wenwen Liu Jie Shen Jiaqi You Tao Wang Pusheng Yang Yaxin Miao Xiaotong Peng Yimin Yu Chengyu Liu Ang Li Jing Sun |
| author_sort | Wenwen Liu |
| collection | DOAJ |
| description | Endometriosis, an estrogen-dependent inflammatory disorder prevalent in reproductive-age women, is characterized by the growth of endometrial-like tissue outside the uterine cavity, leading to chronic pain and infertility. Current therapeutic strategies primarily focus on lesion removal and pain alleviation, often at the cost of compromising ovarian function and natural conception. Herein, we engineered a nanocomposite with polydopamine and dydrogesterone for precise and gentle endometriosis treatment while protecting ovarian function and fertility. It combines polydopamine 's anti-inflammatory and antioxidant capacities with dydrogesterone's ectopic lesion regression capability while maintaining physiological ovulation. To enhance the lesion-specific delivery, the nanocomposite was functionalized with polyethylene glycol and laminin. Through in vitro and in vivo studies, we demonstrate that the nanocomposites exhibit potent antioxidant and anti-inflammatory properties, coupled with targeted delivery to ectopic endometrial cells. The nanocomposites effectively accumulate in ectopic lesions, modulate macrophage polarization, and promote the atrophy and clearance of ectopic endometrial tissue. Importantly, this therapeutic approach preserves ovarian reserve function and fertility, showing no significant adverse effects on ovarian health. In summary, we present an innovation non-surgical therapeutic strategy for endometriosis that demonstrates both safety and efficacy while preserving ovarian reserve function and fertility potential. |
| format | Article |
| id | doaj-art-690bea00f03a42df992ff52f463d09eb |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-690bea00f03a42df992ff52f463d09eb2025-08-20T02:38:46ZengElsevierMaterials Today Bio2590-00642025-08-013310204110.1016/j.mtbio.2025.102041A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviationWenwen Liu0Jie Shen1Jiaqi You2Tao Wang3Pusheng Yang4Yaxin Miao5Xiaotong Peng6Yimin Yu7Chengyu Liu8Ang Li9Jing Sun10The Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, ChinaClinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, ChinaDepartment of Respiratory and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated Shanghai JiaoTong University School of Medicine, No.639, Zhizaoju Road, Shanghai, 200011, ChinaThe Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, ChinaThe Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, ChinaThe Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, ChinaThe Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, ChinaClinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, ChinaClinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, ChinaThe Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China; Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China; Corresponding author. The Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699, West Gaoke Road, Shanghai, 200092, China.The Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China; Corresponding author. The Gynecology Department, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699, West Gaoke Road, Shanghai, 200092, China.Endometriosis, an estrogen-dependent inflammatory disorder prevalent in reproductive-age women, is characterized by the growth of endometrial-like tissue outside the uterine cavity, leading to chronic pain and infertility. Current therapeutic strategies primarily focus on lesion removal and pain alleviation, often at the cost of compromising ovarian function and natural conception. Herein, we engineered a nanocomposite with polydopamine and dydrogesterone for precise and gentle endometriosis treatment while protecting ovarian function and fertility. It combines polydopamine 's anti-inflammatory and antioxidant capacities with dydrogesterone's ectopic lesion regression capability while maintaining physiological ovulation. To enhance the lesion-specific delivery, the nanocomposite was functionalized with polyethylene glycol and laminin. Through in vitro and in vivo studies, we demonstrate that the nanocomposites exhibit potent antioxidant and anti-inflammatory properties, coupled with targeted delivery to ectopic endometrial cells. The nanocomposites effectively accumulate in ectopic lesions, modulate macrophage polarization, and promote the atrophy and clearance of ectopic endometrial tissue. Importantly, this therapeutic approach preserves ovarian reserve function and fertility, showing no significant adverse effects on ovarian health. In summary, we present an innovation non-surgical therapeutic strategy for endometriosis that demonstrates both safety and efficacy while preserving ovarian reserve function and fertility potential.http://www.sciencedirect.com/science/article/pii/S2590006425006118EndometriosisNanocompositesFertilityInflammatoryOxidative stress |
| spellingShingle | Wenwen Liu Jie Shen Jiaqi You Tao Wang Pusheng Yang Yaxin Miao Xiaotong Peng Yimin Yu Chengyu Liu Ang Li Jing Sun A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation Materials Today Bio Endometriosis Nanocomposites Fertility Inflammatory Oxidative stress |
| title | A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation |
| title_full | A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation |
| title_fullStr | A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation |
| title_full_unstemmed | A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation |
| title_short | A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation |
| title_sort | novel fertility sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation |
| topic | Endometriosis Nanocomposites Fertility Inflammatory Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425006118 |
| work_keys_str_mv | AT wenwenliu anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT jieshen anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT jiaqiyou anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT taowang anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT pushengyang anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT yaxinmiao anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT xiaotongpeng anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT yiminyu anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT chengyuliu anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT angli anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT jingsun anovelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT wenwenliu novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT jieshen novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT jiaqiyou novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT taowang novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT pushengyang novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT yaxinmiao novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT xiaotongpeng novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT yiminyu novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT chengyuliu novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT angli novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation AT jingsun novelfertilitysparingnanocompositeforendometriosistreatmentviaoxidativestressandinflammationalleviation |