Health-related quality of life related to diabetes multisensory deficits and derealization
Abstract Two hundred and one adults aged 28 to 80 years (100 without/101 with type 2 diabetes) participated in a cross sectional study to assess the correlation among sensory deficits, depersonalization/derealization, and anxiety/depression symptoms and their contribution to health-related quality o...
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| Format: | Article |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-13356-x |
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| author | Kathrine Jáuregui-Renaud José Adan Miguel-Puga Aida García-López María de Lourdes Tirado-Mondragón Ignacio Figueroa-Padilla Nayeli Scarlett Lara-Angeles Olimpia Chávez-Navarrete |
| author_facet | Kathrine Jáuregui-Renaud José Adan Miguel-Puga Aida García-López María de Lourdes Tirado-Mondragón Ignacio Figueroa-Padilla Nayeli Scarlett Lara-Angeles Olimpia Chávez-Navarrete |
| author_sort | Kathrine Jáuregui-Renaud |
| collection | DOAJ |
| description | Abstract Two hundred and one adults aged 28 to 80 years (100 without/101 with type 2 diabetes) participated in a cross sectional study to assess the correlation among sensory deficits, depersonalization/derealization, and anxiety/depression symptoms and their contribution to health-related quality of life, considering individual characteristics (age, sex, obesity, COVID-19 history). Assessments included: general health, body mass index, sensory deficits (vision/neuropathy/hearing/vestibular), symptoms related to balance, dissociative experiences, depersonalization/derealization and anxiety/depression symptoms, and health-related quality of life. Analyses were performed by bivariate and covariance tests (p ≤ 0.05). Participants with diabetes exhibited multisensory deficits and increased mental symptoms, with reduced health-related quality of life. Anxiety/depression symptoms were mainly related to balance symptoms, significant dissociative experiences and obesity (adjusted R2 = 0.20, p < 0.000001); depersonalization/derealization symptoms were mainly related to sensory deficits, balance and anxiety/depression symptoms (adjusted R2 = 0.48, p < 0.000001). The majority of these variables, along with age contributed to the variance on health-related quality of life (adjusted R2 = 0.43, p < 0.000001). The results support that the sensory deficits related to diabetes may reduce the perceived health-related quality of life by both physical and mental aftereffects, including unreality perceptions; the multisensory integration required for balance may have a particular role on mental health and functioning; assessment of depersonalization/derealization symptoms requires considering sensory deficits. |
| format | Article |
| id | doaj-art-690b85a160ef42cd8d4edc851af76121 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-690b85a160ef42cd8d4edc851af761212025-08-20T03:42:31ZengNature PortfolioScientific Reports2045-23222025-08-0115111310.1038/s41598-025-13356-xHealth-related quality of life related to diabetes multisensory deficits and derealizationKathrine Jáuregui-Renaud0José Adan Miguel-Puga1Aida García-López2María de Lourdes Tirado-Mondragón3Ignacio Figueroa-Padilla4Nayeli Scarlett Lara-Angeles5Olimpia Chávez-Navarrete6Unidad de Investigación Médica en Otoneurología, Instituto Mexicano del Seguro SocialUnidad de Investigación Médica en Otoneurología, Instituto Mexicano del Seguro SocialUnidad de Investigación Médica en Otoneurología, Instituto Mexicano del Seguro SocialHospital General de Zona 8, Instituto Mexicano del Seguro SocialHospital Regional 72, Instituto Mexicano del Seguro Social,Unidad de Medicina Física y de Rehabilitación Siglo XXI, Instituto Mexicano del Seguro SocialHospital General de Zona 32, Instituto Mexicano del Seguro SocialAbstract Two hundred and one adults aged 28 to 80 years (100 without/101 with type 2 diabetes) participated in a cross sectional study to assess the correlation among sensory deficits, depersonalization/derealization, and anxiety/depression symptoms and their contribution to health-related quality of life, considering individual characteristics (age, sex, obesity, COVID-19 history). Assessments included: general health, body mass index, sensory deficits (vision/neuropathy/hearing/vestibular), symptoms related to balance, dissociative experiences, depersonalization/derealization and anxiety/depression symptoms, and health-related quality of life. Analyses were performed by bivariate and covariance tests (p ≤ 0.05). Participants with diabetes exhibited multisensory deficits and increased mental symptoms, with reduced health-related quality of life. Anxiety/depression symptoms were mainly related to balance symptoms, significant dissociative experiences and obesity (adjusted R2 = 0.20, p < 0.000001); depersonalization/derealization symptoms were mainly related to sensory deficits, balance and anxiety/depression symptoms (adjusted R2 = 0.48, p < 0.000001). The majority of these variables, along with age contributed to the variance on health-related quality of life (adjusted R2 = 0.43, p < 0.000001). The results support that the sensory deficits related to diabetes may reduce the perceived health-related quality of life by both physical and mental aftereffects, including unreality perceptions; the multisensory integration required for balance may have a particular role on mental health and functioning; assessment of depersonalization/derealization symptoms requires considering sensory deficits.https://doi.org/10.1038/s41598-025-13356-xDiabetesSensory deficitQuality of lifeDepersonalizationAnxietyDepression |
| spellingShingle | Kathrine Jáuregui-Renaud José Adan Miguel-Puga Aida García-López María de Lourdes Tirado-Mondragón Ignacio Figueroa-Padilla Nayeli Scarlett Lara-Angeles Olimpia Chávez-Navarrete Health-related quality of life related to diabetes multisensory deficits and derealization Scientific Reports Diabetes Sensory deficit Quality of life Depersonalization Anxiety Depression |
| title | Health-related quality of life related to diabetes multisensory deficits and derealization |
| title_full | Health-related quality of life related to diabetes multisensory deficits and derealization |
| title_fullStr | Health-related quality of life related to diabetes multisensory deficits and derealization |
| title_full_unstemmed | Health-related quality of life related to diabetes multisensory deficits and derealization |
| title_short | Health-related quality of life related to diabetes multisensory deficits and derealization |
| title_sort | health related quality of life related to diabetes multisensory deficits and derealization |
| topic | Diabetes Sensory deficit Quality of life Depersonalization Anxiety Depression |
| url | https://doi.org/10.1038/s41598-025-13356-x |
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