Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies.
<h4>Aim</h4>The association between vitamin intake and gastric cancer (GC) has been widely debated due to the relatively weak evidence. In this study, a meta-analysis of prospective and well designed observational studies were performed to explore this association.<h4>Methods</h...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116060&type=printable |
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| author | Pengfei Kong Qingqing Cai Qirong Geng Jing Wang Yadong Lan Youqing Zhan Dazhi Xu |
| author_facet | Pengfei Kong Qingqing Cai Qirong Geng Jing Wang Yadong Lan Youqing Zhan Dazhi Xu |
| author_sort | Pengfei Kong |
| collection | DOAJ |
| description | <h4>Aim</h4>The association between vitamin intake and gastric cancer (GC) has been widely debated due to the relatively weak evidence. In this study, a meta-analysis of prospective and well designed observational studies were performed to explore this association.<h4>Methods</h4>MEDLINE, Cochrane Library, and Sciencedirect were searched for studies of vitamin consumption and gastric cancer. This produced 47 relevant studies covering 1,221,392 human subjects. Random effects models were used to estimate summary relative risk (RR). Dose-response, subgroup, sensitivity, meta-regression, and publication bias analyses were conducted.<h4>Results</h4>The RR of gastric cancer in the group with the highest vitamin intake was compared to that of the lowest intake group. Total vitamin intake was 0.78 (95% CI, 0.71-0.83). In 9 studies that individuals were given doses at least 4 times above the tolerable upper intake (UL) vitamins, the RR was 1.20 (95% CI, 0.99-1.44). However, in 17 studies that individuals received doses below the UL, the RR was 0.76 (95% CI, 0.68-0.86). Dose-response analysis was conducted on different increments in different types of vitamins (vitamin A: 1.5 mg/day, vitamin C: 100 mg/day, vitamin E: 10 mg/day) intake with a significant reduction in the risk of gastric cancer, respectively, 29% in vitamin A, 26% in vitamin C, and 24% in vitamin E.<h4>Conclusion</h4>This meta-analysis clearly demonstrated that low doses of vitamins can significantly reduce the risk of GC, especially vitamin A, vitamin C, vitamin E. |
| format | Article |
| id | doaj-art-6908c12db4124205aae3a46ecfe1ed45 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6908c12db4124205aae3a46ecfe1ed452025-08-20T02:46:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11606010.1371/journal.pone.0116060Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies.Pengfei KongQingqing CaiQirong GengJing WangYadong LanYouqing ZhanDazhi Xu<h4>Aim</h4>The association between vitamin intake and gastric cancer (GC) has been widely debated due to the relatively weak evidence. In this study, a meta-analysis of prospective and well designed observational studies were performed to explore this association.<h4>Methods</h4>MEDLINE, Cochrane Library, and Sciencedirect were searched for studies of vitamin consumption and gastric cancer. This produced 47 relevant studies covering 1,221,392 human subjects. Random effects models were used to estimate summary relative risk (RR). Dose-response, subgroup, sensitivity, meta-regression, and publication bias analyses were conducted.<h4>Results</h4>The RR of gastric cancer in the group with the highest vitamin intake was compared to that of the lowest intake group. Total vitamin intake was 0.78 (95% CI, 0.71-0.83). In 9 studies that individuals were given doses at least 4 times above the tolerable upper intake (UL) vitamins, the RR was 1.20 (95% CI, 0.99-1.44). However, in 17 studies that individuals received doses below the UL, the RR was 0.76 (95% CI, 0.68-0.86). Dose-response analysis was conducted on different increments in different types of vitamins (vitamin A: 1.5 mg/day, vitamin C: 100 mg/day, vitamin E: 10 mg/day) intake with a significant reduction in the risk of gastric cancer, respectively, 29% in vitamin A, 26% in vitamin C, and 24% in vitamin E.<h4>Conclusion</h4>This meta-analysis clearly demonstrated that low doses of vitamins can significantly reduce the risk of GC, especially vitamin A, vitamin C, vitamin E.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116060&type=printable |
| spellingShingle | Pengfei Kong Qingqing Cai Qirong Geng Jing Wang Yadong Lan Youqing Zhan Dazhi Xu Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. PLoS ONE |
| title | Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. |
| title_full | Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. |
| title_fullStr | Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. |
| title_full_unstemmed | Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. |
| title_short | Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. |
| title_sort | vitamin intake reduce the risk of gastric cancer meta analysis and systematic review of randomized and observational studies |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116060&type=printable |
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