Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation
The authors provide the results of colloid hepatic scintigraphy and whole body studies, by determining the hepatic and splenic uptake of the radiotracer in 105 patients with hepatic cirrhosis (HC) of different etiology. The results obtained in the groups of patients with varying HC according to the...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/280 |
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| author | E. N. Khodareva O. G. Sinyakova A. V. Chzhao O. I. Andreitseva N. E. Kudryashova |
| author_facet | E. N. Khodareva O. G. Sinyakova A. V. Chzhao O. I. Andreitseva N. E. Kudryashova |
| author_sort | E. N. Khodareva |
| collection | DOAJ |
| description | The authors provide the results of colloid hepatic scintigraphy and whole body studies, by determining the hepatic and splenic uptake of the radiotracer in 105 patients with hepatic cirrhosis (HC) of different etiology. The results obtained in the groups of patients with varying HC according to the Child-Pugh classification and in the group of 11 healthy volunteers were compared. The results were analyzed in 17 patients prior to and following liver transplantation. In the Child-Pugh B-C groups, the liver showed a tendency to be reduced along with progressive splenic enlargement and radiocolloid redistribution towards the spleen and bone marrow with the most significant differences in the relative splenic and bone marrow uptake of the radiotracer (p < 0.005) and its hepatic capture in percentage of the whole body (p < 0.001). One-six months after surgery, there was a significant improvement of all parameters with obvious regression of the signs of portal hypertension in the patients who had undergone liver transplantation. Colloid hepatic scintigraphy has been shown to be a highly informative technique in assessing liver function in patients with HC; it also permits evaluation of the regression of symptoms of portal hypertension and the functional state of a liver graft in the postoperative period. |
| format | Article |
| id | doaj-art-690213fdca084778b9c9780a8d904ab2 |
| institution | DOAJ |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-690213fdca084778b9c9780a8d904ab22025-08-20T02:55:45ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092018-08-0102303410.23873/2074-0506-2010-0-2-30-34269Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantationE. N. Khodareva0O. G. Sinyakova1A. V. Chzhao2O. I. Andreitseva3N. E. Kudryashova4N.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareThe authors provide the results of colloid hepatic scintigraphy and whole body studies, by determining the hepatic and splenic uptake of the radiotracer in 105 patients with hepatic cirrhosis (HC) of different etiology. The results obtained in the groups of patients with varying HC according to the Child-Pugh classification and in the group of 11 healthy volunteers were compared. The results were analyzed in 17 patients prior to and following liver transplantation. In the Child-Pugh B-C groups, the liver showed a tendency to be reduced along with progressive splenic enlargement and radiocolloid redistribution towards the spleen and bone marrow with the most significant differences in the relative splenic and bone marrow uptake of the radiotracer (p < 0.005) and its hepatic capture in percentage of the whole body (p < 0.001). One-six months after surgery, there was a significant improvement of all parameters with obvious regression of the signs of portal hypertension in the patients who had undergone liver transplantation. Colloid hepatic scintigraphy has been shown to be a highly informative technique in assessing liver function in patients with HC; it also permits evaluation of the regression of symptoms of portal hypertension and the functional state of a liver graft in the postoperative period.https://www.jtransplantologiya.ru/jour/article/view/280colloid hepatic scintigraphy99мtc-technephytecolloid distribution in the liver and spleenchild-pugh classificationliver transplantation |
| spellingShingle | E. N. Khodareva O. G. Sinyakova A. V. Chzhao O. I. Andreitseva N. E. Kudryashova Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation Трансплантология (Москва) colloid hepatic scintigraphy 99мtc-technephyte colloid distribution in the liver and spleen child-pugh classification liver transplantation |
| title | Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation |
| title_full | Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation |
| title_fullStr | Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation |
| title_full_unstemmed | Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation |
| title_short | Value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation |
| title_sort | value of colloid hepatic scintigraphy in the evaluation of the condition of patients with hepatic cirrhosis and the functional status of the liver before and after transplantation |
| topic | colloid hepatic scintigraphy 99мtc-technephyte colloid distribution in the liver and spleen child-pugh classification liver transplantation |
| url | https://www.jtransplantologiya.ru/jour/article/view/280 |
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