The DUF1669 domain of FAM83H is required for its localization to nuclear speckles

The DUF1669 domain of FAM83H is required for its localization to nuclear speckles

Abstract Autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI) is caused by mutations in the FAM83H gene. Mutated FAM83H genes encode truncated FAM83H proteins with amino acid lengths between amino acids 1–286 and 1–693, in contrast to wild-type FAM83H (1–1179). Deletion of the C-terminu...

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Bibliographic Details
Main Authors: Takahisa Kuga, Minami Saraya, Sora Higuchi, Shun Yoshida, Shino Murataka, Yuri Fujiwara, Yudai Tomita, Sayo Hayama, Yuichiro Kaibori, Nobuyuki Yamagishi
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
FAM83H
Amelogenesis imperfecta
Casein kinase I
Nuclear speckles
Online Access:https://doi.org/10.1038/s41598-025-96356-1
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