Hyperferritinemia at the patient with chronic hepatitis C
The aim of clinical case presentation. To represent the patient with chronic hepatitis C with severe hyperferritinemia and absence of dominant mutations of hereditary hemochromatosis gene.Clinical case data. Patient К., 38 years, despite of rapid virologic response at combined antiviral therapy by p...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2009-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1605 |
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| author | Ye. N. German A. O. Buyeverov M. V. Mayevskaya Ch. S. Pavlov V. T. Ivashkin A. A. Levina |
| author_facet | Ye. N. German A. O. Buyeverov M. V. Mayevskaya Ch. S. Pavlov V. T. Ivashkin A. A. Levina |
| author_sort | Ye. N. German |
| collection | DOAJ |
| description | The aim of clinical case presentation. To represent the patient with chronic hepatitis C with severe hyperferritinemia and absence of dominant mutations of hereditary hemochromatosis gene.Clinical case data. Patient К., 38 years, despite of rapid virologic response at combined antiviral therapy by pegilated interferon α-2а and ribavirin, had persistently high activity of transaminases and initially high level of serum ferritin increase twice.Conclusion. Retrospective evaluation of developed clinical situation allows to assume, that ferritin in this case acted as acute-phase protein. On the other hand, taking into account high level of serum transaminases and lymphadenopathy (developed at the 20-th week of treatment), atypical side effect of the antiviral agents of idiosyncrasy type can be suspected. After cessation of the treatment course clinical and laboratory abnormalities reduced. Sustained virologic response was ascertained. |
| format | Article |
| id | doaj-art-68e9be5be8464733801bb798b489e497 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2009-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-68e9be5be8464733801bb798b489e4972025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732009-02-0119171771110Hyperferritinemia at the patient with chronic hepatitis CYe. N. GermanA. O. BuyeverovM. V. MayevskayaCh. S. PavlovV. T. IvashkinA. A. LevinaThe aim of clinical case presentation. To represent the patient with chronic hepatitis C with severe hyperferritinemia and absence of dominant mutations of hereditary hemochromatosis gene.Clinical case data. Patient К., 38 years, despite of rapid virologic response at combined antiviral therapy by pegilated interferon α-2а and ribavirin, had persistently high activity of transaminases and initially high level of serum ferritin increase twice.Conclusion. Retrospective evaluation of developed clinical situation allows to assume, that ferritin in this case acted as acute-phase protein. On the other hand, taking into account high level of serum transaminases and lymphadenopathy (developed at the 20-th week of treatment), atypical side effect of the antiviral agents of idiosyncrasy type can be suspected. After cessation of the treatment course clinical and laboratory abnormalities reduced. Sustained virologic response was ascertained.https://www.gastro-j.ru/jour/article/view/1605hepatitis cferritinsyndrome of iron overloadtreatment |
| spellingShingle | Ye. N. German A. O. Buyeverov M. V. Mayevskaya Ch. S. Pavlov V. T. Ivashkin A. A. Levina Hyperferritinemia at the patient with chronic hepatitis C Российский журнал гастроэнтерологии, гепатологии, колопроктологии hepatitis c ferritin syndrome of iron overload treatment |
| title | Hyperferritinemia at the patient with chronic hepatitis C |
| title_full | Hyperferritinemia at the patient with chronic hepatitis C |
| title_fullStr | Hyperferritinemia at the patient with chronic hepatitis C |
| title_full_unstemmed | Hyperferritinemia at the patient with chronic hepatitis C |
| title_short | Hyperferritinemia at the patient with chronic hepatitis C |
| title_sort | hyperferritinemia at the patient with chronic hepatitis c |
| topic | hepatitis c ferritin syndrome of iron overload treatment |
| url | https://www.gastro-j.ru/jour/article/view/1605 |
| work_keys_str_mv | AT yengerman hyperferritinemiaatthepatientwithchronichepatitisc AT aobuyeverov hyperferritinemiaatthepatientwithchronichepatitisc AT mvmayevskaya hyperferritinemiaatthepatientwithchronichepatitisc AT chspavlov hyperferritinemiaatthepatientwithchronichepatitisc AT vtivashkin hyperferritinemiaatthepatientwithchronichepatitisc AT aalevina hyperferritinemiaatthepatientwithchronichepatitisc |