An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent
Invasive aspergillosis is a life-threatening infectious complication in immunocompromised patients, especially with malignancy, and in some cases, it causes extensive tissue destruction and subsequent systemic illness, leading to multiorgan failure and death. Skin involvement and amphotericin B resi...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957213001897 |
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| author | Aslinur Ozkaya-Parlakay Buse Ozer-Bekmez Ates Kara Baris Kuskonmaz Zuhal Akcoren Sevtap Arikan-Dagli Berna Oguz |
| author_facet | Aslinur Ozkaya-Parlakay Buse Ozer-Bekmez Ates Kara Baris Kuskonmaz Zuhal Akcoren Sevtap Arikan-Dagli Berna Oguz |
| author_sort | Aslinur Ozkaya-Parlakay |
| collection | DOAJ |
| description | Invasive aspergillosis is a life-threatening infectious complication in immunocompromised patients, especially with malignancy, and in some cases, it causes extensive tissue destruction and subsequent systemic illness, leading to multiorgan failure and death. Skin involvement and amphotericin B resistance are very rare findings of aspergillosis. Herein, we report the case of a primary hemophagocytic syndrome patient who developed subcutaneous nodules in the 3rd month of bone marrow transplantation from which Aspergillus fumigatus was cultivated despite the fact that she was under antifungal therapy. In immunocompromised patients with prolonged fever, atypical presentations of invasive mycosis should be kept in mind, and early appropriate therapy should be initiated promptly to decrease morbidity and mortality. |
| format | Article |
| id | doaj-art-68e8fba97ae84c708d593e43a8a0b01a |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-68e8fba97ae84c708d593e43a8a0b01a2025-08-20T03:18:19ZengElsevierPediatrics and Neonatology1875-95722016-08-0157434334610.1016/j.pedneo.2013.09.010An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an AdolescentAslinur Ozkaya-Parlakay0Buse Ozer-Bekmez1Ates Kara2Baris Kuskonmaz3Zuhal Akcoren4Sevtap Arikan-Dagli5Berna Oguz6Hacettepe University Medical Faculty, Pediatric Infectious Disease Department, Ankara, TurkeyHacettepe University Medical Faculty, Pediatrics Department, Ankara, TurkeyHacettepe University Medical Faculty, Pediatric Infectious Disease Department, Ankara, TurkeyHacettepe University Medical Faculty, Pediatric Hematology Department, Ankara, TurkeyHacettepe University Medical Faculty, Pediatric Pathology Department, Ankara, TurkeyHacettepe University Medical Faculty, Mycology Department, Ankara, TurkeyHacettepe University Medical Faculty, Radiology Department, Ankara, TurkeyInvasive aspergillosis is a life-threatening infectious complication in immunocompromised patients, especially with malignancy, and in some cases, it causes extensive tissue destruction and subsequent systemic illness, leading to multiorgan failure and death. Skin involvement and amphotericin B resistance are very rare findings of aspergillosis. Herein, we report the case of a primary hemophagocytic syndrome patient who developed subcutaneous nodules in the 3rd month of bone marrow transplantation from which Aspergillus fumigatus was cultivated despite the fact that she was under antifungal therapy. In immunocompromised patients with prolonged fever, atypical presentations of invasive mycosis should be kept in mind, and early appropriate therapy should be initiated promptly to decrease morbidity and mortality.http://www.sciencedirect.com/science/article/pii/S1875957213001897Aspergillus fumigatuschildprimary hemophagocytic syndromeskin |
| spellingShingle | Aslinur Ozkaya-Parlakay Buse Ozer-Bekmez Ates Kara Baris Kuskonmaz Zuhal Akcoren Sevtap Arikan-Dagli Berna Oguz An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent Pediatrics and Neonatology Aspergillus fumigatus child primary hemophagocytic syndrome skin |
| title | An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent |
| title_full | An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent |
| title_fullStr | An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent |
| title_full_unstemmed | An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent |
| title_short | An Important Finding of Systemic Aspergillosis: Skin Involvement and Amphotericin B Resistance in an Adolescent |
| title_sort | important finding of systemic aspergillosis skin involvement and amphotericin b resistance in an adolescent |
| topic | Aspergillus fumigatus child primary hemophagocytic syndrome skin |
| url | http://www.sciencedirect.com/science/article/pii/S1875957213001897 |
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