De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs are the cause of almost all cervical cancers and a sub-set of other epithelial malignancies including head and neck cancers, specifically within the oropharynx. The oncogenic properties of HPV are largel...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Tumour Virus Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666679025000023 |
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| author | Kemi Hannah Oladipo Joanna L. Parish |
| author_facet | Kemi Hannah Oladipo Joanna L. Parish |
| author_sort | Kemi Hannah Oladipo |
| collection | DOAJ |
| description | Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs are the cause of almost all cervical cancers and a sub-set of other epithelial malignancies including head and neck cancers, specifically within the oropharynx. The oncogenic properties of HPV are largely mediated through the viral oncoproteins E6 and E7, which disrupt many cellular pathways to drive uncontrolled cell proliferation. One family of proteins targeted by HPV is the Aurora kinase family. Aurora kinases are serine/threonine kinases including Aurora kinase A (AURKA), B (AURKB), and C (AURKC) which are often dysregulated in many cancer types, including HPV driven cancers. All three family members play essential roles in mitotic regulation and accurate cell division.The deregulation of Aurora kinases by HPV infection highlights their potential as therapeutic targets in HPV-associated malignancies. Targeting Aurora kinase activity, in combination with current HPV therapies, may provide new avenues for treating HPV-induced cancers and reducing the burden of HPV-related diseases. Combinatorial inhibition targets distinct but overlapping functions of these kinases, thereby reducing the potential for cancer cells to develop resistance. This broad impact emphasizes the capability for Aurora kinase inhibitors not only as anti-mitotic agents but also as modulators of multiple oncogenic pathways. This review explores the combinatorial effects of Aurora kinase inhibition, offering insights into novel therapeutic strategies for the treatment of HPV-driven cancers. |
| format | Article |
| id | doaj-art-68e8b81531a74ffa9e9b24eba53e2fa0 |
| institution | DOAJ |
| issn | 2666-6790 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tumour Virus Research |
| spelling | doaj-art-68e8b81531a74ffa9e9b24eba53e2fa02025-08-20T02:39:38ZengElsevierTumour Virus Research2666-67902025-06-011920031410.1016/j.tvr.2025.200314De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatmentKemi Hannah Oladipo0Joanna L. Parish1Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom; Corresponding author;National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United KingdomDepartment of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United KingdomHuman papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs are the cause of almost all cervical cancers and a sub-set of other epithelial malignancies including head and neck cancers, specifically within the oropharynx. The oncogenic properties of HPV are largely mediated through the viral oncoproteins E6 and E7, which disrupt many cellular pathways to drive uncontrolled cell proliferation. One family of proteins targeted by HPV is the Aurora kinase family. Aurora kinases are serine/threonine kinases including Aurora kinase A (AURKA), B (AURKB), and C (AURKC) which are often dysregulated in many cancer types, including HPV driven cancers. All three family members play essential roles in mitotic regulation and accurate cell division.The deregulation of Aurora kinases by HPV infection highlights their potential as therapeutic targets in HPV-associated malignancies. Targeting Aurora kinase activity, in combination with current HPV therapies, may provide new avenues for treating HPV-induced cancers and reducing the burden of HPV-related diseases. Combinatorial inhibition targets distinct but overlapping functions of these kinases, thereby reducing the potential for cancer cells to develop resistance. This broad impact emphasizes the capability for Aurora kinase inhibitors not only as anti-mitotic agents but also as modulators of multiple oncogenic pathways. This review explores the combinatorial effects of Aurora kinase inhibition, offering insights into novel therapeutic strategies for the treatment of HPV-driven cancers.http://www.sciencedirect.com/science/article/pii/S2666679025000023HPVAurora kinasesCancerDNA virusTumour virusAurora a |
| spellingShingle | Kemi Hannah Oladipo Joanna L. Parish De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment Tumour Virus Research HPV Aurora kinases Cancer DNA virus Tumour virus Aurora a |
| title | De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment |
| title_full | De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment |
| title_fullStr | De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment |
| title_full_unstemmed | De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment |
| title_short | De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment |
| title_sort | de regulation of aurora kinases by oncogenic hpv implications in cancer development and treatment |
| topic | HPV Aurora kinases Cancer DNA virus Tumour virus Aurora a |
| url | http://www.sciencedirect.com/science/article/pii/S2666679025000023 |
| work_keys_str_mv | AT kemihannaholadipo deregulationofaurorakinasesbyoncogenichpvimplicationsincancerdevelopmentandtreatment AT joannalparish deregulationofaurorakinasesbyoncogenichpvimplicationsincancerdevelopmentandtreatment |