Structural insights into the human HRD1 ubiquitin ligase complex

Structural insights into the human HRD1 ubiquitin ligase complex

Abstract In the endoplasmic reticulum (ER), defective proteins are cleaned via the ER-associated protein degradation (ERAD) pathway. The HRD1 ubiquitin ligase complex, with HRD1, SEL1L, XTP3B or OS9 and Derlin family proteins as the core components, plays essential roles in the recognition, retrotra...

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Bibliographic Details
Main Authors: Liling Guo, Guoyun Liu, Jingjing He, Xiaoxiao Jia, Yonglin He, Zhenhua Wang, Hongwu Qian
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61143-z
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