CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY
Various disturbances in the interferon system (IFN) — interferonopathy are considered. The classification of developed by the author is given. The clinical features of Type I interferonopathy associated with the overexpression of type I interferons in the rare Mendelian genetic diseases, some autoim...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Diagnostics and Vaccines"
2017-07-01
|
| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/295 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850232350278942720 |
|---|---|
| author | I. V. Nesterova |
| author_facet | I. V. Nesterova |
| author_sort | I. V. Nesterova |
| collection | DOAJ |
| description | Various disturbances in the interferon system (IFN) — interferonopathy are considered. The classification of developed by the author is given. The clinical features of Type I interferonopathy associated with the overexpression of type I interferons in the rare Mendelian genetic diseases, some autoimmune diseases, the immune dysregulation syndrome, are characterized. The developed methods of targeted therapy of type I interferonopathies aimed at blocking overexpression of type I interferons as hyperproduction IFNa are described. Interferonopathies most often occur as IFN deficiency: congenital or acquired IFNa/b and IFNg deficiencies in children and adults who are associated with atypical viral or mycobacterial infections. Patients with congenital IFNa deficiency are shown to have replacement interferon therapy. With the acquired deficiency of IFNa, differentiated interferon-corrective therapy is performed. For replacement and interferon-corrective therapy, it is used with good clinical efficacy, safe, no side effects, recombinant human IFNa2b in combination with antioxidants — VIFERONR. |
| format | Article |
| id | doaj-art-68e405a135b64b5aa9dd6bda5a444dae |
| institution | OA Journals |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2017-07-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-68e405a135b64b5aa9dd6bda5a444dae2025-08-20T02:03:13ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072017-07-01162505310.22627/2072-8107-2017-16-2-50-53285CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPYI. V. Nesterova0People’s Friendship University of RussiaVarious disturbances in the interferon system (IFN) — interferonopathy are considered. The classification of developed by the author is given. The clinical features of Type I interferonopathy associated with the overexpression of type I interferons in the rare Mendelian genetic diseases, some autoimmune diseases, the immune dysregulation syndrome, are characterized. The developed methods of targeted therapy of type I interferonopathies aimed at blocking overexpression of type I interferons as hyperproduction IFNa are described. Interferonopathies most often occur as IFN deficiency: congenital or acquired IFNa/b and IFNg deficiencies in children and adults who are associated with atypical viral or mycobacterial infections. Patients with congenital IFNa deficiency are shown to have replacement interferon therapy. With the acquired deficiency of IFNa, differentiated interferon-corrective therapy is performed. For replacement and interferon-corrective therapy, it is used with good clinical efficacy, safe, no side effects, recombinant human IFNa2b in combination with antioxidants — VIFERONR.https://detinf.elpub.ru/jour/article/view/295interferonopathyoverexpression of type i interferonscongenital or acquired ifn/and ifndeficienciestargeted therapyreplacementcorrective interferon-therapy |
| spellingShingle | I. V. Nesterova CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY Детские инфекции (Москва) interferonopathy overexpression of type i interferons congenital or acquired ifn/and ifndeficiencies targeted therapy replacement corrective interferon-therapy |
| title | CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY |
| title_full | CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY |
| title_fullStr | CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY |
| title_full_unstemmed | CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY |
| title_short | CONGENITAL AND ACQUIRED INTERFERONOPATHIES: DIFFERENTIATED APPROACHES TO THE INTERFERON-CORRECTIVE THERAPY |
| title_sort | congenital and acquired interferonopathies differentiated approaches to the interferon corrective therapy |
| topic | interferonopathy overexpression of type i interferons congenital or acquired ifn/and ifndeficiencies targeted therapy replacement corrective interferon-therapy |
| url | https://detinf.elpub.ru/jour/article/view/295 |
| work_keys_str_mv | AT ivnesterova congenitalandacquiredinterferonopathiesdifferentiatedapproachestotheinterferoncorrectivetherapy |