Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the NOTCH3 gene, resulting in a mutated...

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Main Authors: Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
CADASIL
immunization
NOTCH3
small vessel disease
therapy
Online Access:https://doi.org/10.15252/emmm.202216556
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