Identification of a rare variant in TNNT3 responsible for familial dilated cardiomyopathy through whole-exome sequencing and in silico analysis

Identification of a rare variant in TNNT3 responsible for familial dilated cardiomyopathy through whole-exome sequencing and in silico analysis

Abstract Background Dilated cardiomyopathy (DCM) is a prevalent etiology of heart failure, distinguished by the gradual and frequently irreversible myocardial muscle impairment. Roughly 50% of DCM occurrences stem from hereditary rare variants. In this study, our aim was to identify the genetic caus...

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Bibliographic Details
Main Authors: Motahareh Jadidi, Vida Babaali, Kolsoum InanlooRahatloo, Najmeh Salehi, Reza Mollazadeh
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Dilated cardiomyopathy
DCM
Whole-exome sequencing
Troponin T
TNNT3
Online Access:https://doi.org/10.1186/s40001-025-02692-3
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