Interplay of epigenetics and epistasis drives oral submucous fibrosis
Abstract Persistent injury to oral mucosa due to habitual quid chewing, resulting in the upregulation of inflammatory cytokines and consequential myofibroblastic persistence, emphasizes the role of epigenetic aberration in the pathogenesis of oral submucous fibrosis (OSF). However, there is a dearth...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-08-01
|
| Series: | Discover Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s42452-025-07571-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849234621491838976 |
|---|---|
| author | Mohit Sharma Smitha Sammith Shetty Faisal Alhedyan Raghu Radhakrishnan |
| author_facet | Mohit Sharma Smitha Sammith Shetty Faisal Alhedyan Raghu Radhakrishnan |
| author_sort | Mohit Sharma |
| collection | DOAJ |
| description | Abstract Persistent injury to oral mucosa due to habitual quid chewing, resulting in the upregulation of inflammatory cytokines and consequential myofibroblastic persistence, emphasizes the role of epigenetic aberration in the pathogenesis of oral submucous fibrosis (OSF). However, there is a dearth of research on the role epistasis plays in the pathophysiology of OSF. Among the important epistatic interactions in the pathophysiology of OSF are those between Phosphatase and Tensin Homologue (PTEN) and Insulin-Like Growth Factor 1, Transforming Growth Factor-β (TGF-β), Cyclooxygenases, and lipoxygenases (LOX). Additionally, PTEN and Nuclear Factor Kappa B (NF-κB) have an epistatic relationship that is particularly mediated by the p65 subunit of NF-κB. Given the importance of epigenetic modification in the pathogenesis of OSF, the potential use of DNA methyltransferase and Histone deacetylase inhibitors as a therapeutic option holds promise. Another in vivo epigenetic therapeutic option for treating OSF is using stimulatory microRNAs against antifibrotic genes and inhibitory microRNAs against profibrotic genes. This review aims to connect numerous epigenetic and epistatic components to the mechanism of OSF. A better understanding of the disease process may provide OSF management with newer therapeutic options. Graphical Abstract |
| format | Article |
| id | doaj-art-68d1f145c9e34bd2ae739da28da2c5d8 |
| institution | Kabale University |
| issn | 3004-9261 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Applied Sciences |
| spelling | doaj-art-68d1f145c9e34bd2ae739da28da2c5d82025-08-20T04:03:06ZengSpringerDiscover Applied Sciences3004-92612025-08-017812310.1007/s42452-025-07571-4Interplay of epigenetics and epistasis drives oral submucous fibrosisMohit Sharma0Smitha Sammith Shetty1Faisal Alhedyan2Raghu Radhakrishnan3Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, SGT UniversityDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher EducationDepartment of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz UniversityDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher EducationAbstract Persistent injury to oral mucosa due to habitual quid chewing, resulting in the upregulation of inflammatory cytokines and consequential myofibroblastic persistence, emphasizes the role of epigenetic aberration in the pathogenesis of oral submucous fibrosis (OSF). However, there is a dearth of research on the role epistasis plays in the pathophysiology of OSF. Among the important epistatic interactions in the pathophysiology of OSF are those between Phosphatase and Tensin Homologue (PTEN) and Insulin-Like Growth Factor 1, Transforming Growth Factor-β (TGF-β), Cyclooxygenases, and lipoxygenases (LOX). Additionally, PTEN and Nuclear Factor Kappa B (NF-κB) have an epistatic relationship that is particularly mediated by the p65 subunit of NF-κB. Given the importance of epigenetic modification in the pathogenesis of OSF, the potential use of DNA methyltransferase and Histone deacetylase inhibitors as a therapeutic option holds promise. Another in vivo epigenetic therapeutic option for treating OSF is using stimulatory microRNAs against antifibrotic genes and inhibitory microRNAs against profibrotic genes. This review aims to connect numerous epigenetic and epistatic components to the mechanism of OSF. A better understanding of the disease process may provide OSF management with newer therapeutic options. Graphical Abstracthttps://doi.org/10.1007/s42452-025-07571-4Oral submucous fibrosisEpigenomicsEpistasisDNA methyltransferasesHistone deacetylase inhibitors |
| spellingShingle | Mohit Sharma Smitha Sammith Shetty Faisal Alhedyan Raghu Radhakrishnan Interplay of epigenetics and epistasis drives oral submucous fibrosis Discover Applied Sciences Oral submucous fibrosis Epigenomics Epistasis DNA methyltransferases Histone deacetylase inhibitors |
| title | Interplay of epigenetics and epistasis drives oral submucous fibrosis |
| title_full | Interplay of epigenetics and epistasis drives oral submucous fibrosis |
| title_fullStr | Interplay of epigenetics and epistasis drives oral submucous fibrosis |
| title_full_unstemmed | Interplay of epigenetics and epistasis drives oral submucous fibrosis |
| title_short | Interplay of epigenetics and epistasis drives oral submucous fibrosis |
| title_sort | interplay of epigenetics and epistasis drives oral submucous fibrosis |
| topic | Oral submucous fibrosis Epigenomics Epistasis DNA methyltransferases Histone deacetylase inhibitors |
| url | https://doi.org/10.1007/s42452-025-07571-4 |
| work_keys_str_mv | AT mohitsharma interplayofepigeneticsandepistasisdrivesoralsubmucousfibrosis AT smithasammithshetty interplayofepigeneticsandepistasisdrivesoralsubmucousfibrosis AT faisalalhedyan interplayofepigeneticsandepistasisdrivesoralsubmucousfibrosis AT raghuradhakrishnan interplayofepigeneticsandepistasisdrivesoralsubmucousfibrosis |