Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection
Hypovitaminosis D and secondary hyperparathyroidism are frequent among HIV-infected patients. As there are no data about the best supplementation therapy both in treatment and in maintenance, we conducted an observational study of 300 HIV-infected patients for whom vitamin D and parathormone (PTH) h...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2016/5120831 |
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| author | Elisabet Lerma-Chippirraz Roberto Güerri-Fernández Judit Villar García Alicia González Mena Ana Guelar Grinberg María Milagro Montero Luisa Sorli Sonia Calzado Juan Pablo Horcajada Adolfo Díez-Pérez Hernando Knobel Freud |
| author_facet | Elisabet Lerma-Chippirraz Roberto Güerri-Fernández Judit Villar García Alicia González Mena Ana Guelar Grinberg María Milagro Montero Luisa Sorli Sonia Calzado Juan Pablo Horcajada Adolfo Díez-Pérez Hernando Knobel Freud |
| author_sort | Elisabet Lerma-Chippirraz |
| collection | DOAJ |
| description | Hypovitaminosis D and secondary hyperparathyroidism are frequent among HIV-infected patients. As there are no data about the best supplementation therapy both in treatment and in maintenance, we conducted an observational study of 300 HIV-infected patients for whom vitamin D and parathormone (PTH) had been measured in order to validate a protocol of vitamin D supplementation in patients with HIV-infection. Patients with vitamin D deficiency (defined as 25(OH)D < 10 ng/mL), insufficiency (defined as 25(OH)D < 20 ng/mL), or hyperparathyroidism (PTH > 65 pg/mL) were supplemented with cholecalciferol 16.000IU (0.266 mg) weekly (if deficiency) or fortnightly (if insufficiency or high PTH levels). Rates of normalization of 25(OH)D (levels above 20 ng/mL) and PTH levels (<65 pg/mL) were analyzed. Multivariate analysis of factors related to normalization was carried out. With a median follow-up of 2 years, 82.1% of patients with deficiency and 83.9% of cases with insufficiency reached levels above 20 ng/mL. However, only 67.2% of individuals with hyperparathyroidism at baseline reached target levels (<65 pg/mL). Independent factors for not achieving PTH objective were tenofovir (TDF) and protease inhibitors use. In HIV-infected patients with hypovitaminosis, the protocol of cholecalciferol supplementation normalized vitamin D levels regardless of antiretroviral regimen in a high proportion of patients but it was less effective to correct hyperparathyroidism. |
| format | Article |
| id | doaj-art-68d0bdff28664dbab0e1924058b70b62 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-68d0bdff28664dbab0e1924058b70b622025-02-03T05:52:08ZengWileyAIDS Research and Treatment2090-12402090-12592016-01-01201610.1155/2016/51208315120831Validation Protocol of Vitamin D Supplementation in Patients with HIV-InfectionElisabet Lerma-Chippirraz0Roberto Güerri-Fernández1Judit Villar García2Alicia González Mena3Ana Guelar Grinberg4María Milagro Montero5Luisa Sorli6Sonia Calzado7Juan Pablo Horcajada8Adolfo Díez-Pérez9Hernando Knobel Freud10Hospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Barcelona, SpainHospital del Mar, Infectious Diseases, Barcelona, SpainHypovitaminosis D and secondary hyperparathyroidism are frequent among HIV-infected patients. As there are no data about the best supplementation therapy both in treatment and in maintenance, we conducted an observational study of 300 HIV-infected patients for whom vitamin D and parathormone (PTH) had been measured in order to validate a protocol of vitamin D supplementation in patients with HIV-infection. Patients with vitamin D deficiency (defined as 25(OH)D < 10 ng/mL), insufficiency (defined as 25(OH)D < 20 ng/mL), or hyperparathyroidism (PTH > 65 pg/mL) were supplemented with cholecalciferol 16.000IU (0.266 mg) weekly (if deficiency) or fortnightly (if insufficiency or high PTH levels). Rates of normalization of 25(OH)D (levels above 20 ng/mL) and PTH levels (<65 pg/mL) were analyzed. Multivariate analysis of factors related to normalization was carried out. With a median follow-up of 2 years, 82.1% of patients with deficiency and 83.9% of cases with insufficiency reached levels above 20 ng/mL. However, only 67.2% of individuals with hyperparathyroidism at baseline reached target levels (<65 pg/mL). Independent factors for not achieving PTH objective were tenofovir (TDF) and protease inhibitors use. In HIV-infected patients with hypovitaminosis, the protocol of cholecalciferol supplementation normalized vitamin D levels regardless of antiretroviral regimen in a high proportion of patients but it was less effective to correct hyperparathyroidism.http://dx.doi.org/10.1155/2016/5120831 |
| spellingShingle | Elisabet Lerma-Chippirraz Roberto Güerri-Fernández Judit Villar García Alicia González Mena Ana Guelar Grinberg María Milagro Montero Luisa Sorli Sonia Calzado Juan Pablo Horcajada Adolfo Díez-Pérez Hernando Knobel Freud Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection AIDS Research and Treatment |
| title | Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection |
| title_full | Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection |
| title_fullStr | Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection |
| title_full_unstemmed | Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection |
| title_short | Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection |
| title_sort | validation protocol of vitamin d supplementation in patients with hiv infection |
| url | http://dx.doi.org/10.1155/2016/5120831 |
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