Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses
Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses. R.M. Balabanova, E. V. Vratskih, T.P. Ospelnikova, V.l. Kiseleva Objective. To assess interferon (IFN) status state in pts with rheumatoid arthritis (RA) associated with hepatitis В and С viruses and cry...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2003-08-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1203 |
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| author | R M Balabanova E V Vralskih T P Ospelnikova V I Kiseleva |
| author_facet | R M Balabanova E V Vralskih T P Ospelnikova V I Kiseleva |
| author_sort | R M Balabanova |
| collection | DOAJ |
| description | Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses. R.M. Balabanova, E. V. Vratskih, T.P. Ospelnikova, V.l. Kiseleva Objective. To assess interferon (IFN) status state in pts with rheumatoid arthritis (RA) associated with hepatitis В and С viruses and cryoglobulinemia (CGM). Material and methods. IFN status was assessed in 74 pts with definite RA divided in 4 groups: infected with viruses of hepatitis С (HCV) and В (HBV) (respectively group 1 and 2), RA with CGM (group 3), RA without hepatitis В, С and CGM. IFN status indices were assessed with micromethod in hole heparinized blood. Results. Hepatitis viruses carriers (groups 1 and 2) had significantly elevated circulating IFN level and deep immunocytes IFN producing ability down regulation. In HBV+ RA pts and IFN production decrease was maximal (degree III), in HCV+ RA pts - weaker (degree II). Conclusion. IFN status examination in pts with RA associated with hepatitis viruses and CGM has not only theoretical but also practical importance. Actuality of further study of this problem is determined by necessity of appropriate treatment selection considering IFN system pathology. |
| format | Article |
| id | doaj-art-68d01f5a0dc448f793b3ccebe57d510a |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2003-08-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-68d01f5a0dc448f793b3ccebe57d510a2025-08-20T04:00:39ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922003-08-01414151810.14412/1995-4484-2003-13251143Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С virusesR M BalabanovaE V VralskihT P OspelnikovaV I KiselevaInterferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses. R.M. Balabanova, E. V. Vratskih, T.P. Ospelnikova, V.l. Kiseleva Objective. To assess interferon (IFN) status state in pts with rheumatoid arthritis (RA) associated with hepatitis В and С viruses and cryoglobulinemia (CGM). Material and methods. IFN status was assessed in 74 pts with definite RA divided in 4 groups: infected with viruses of hepatitis С (HCV) and В (HBV) (respectively group 1 and 2), RA with CGM (group 3), RA without hepatitis В, С and CGM. IFN status indices were assessed with micromethod in hole heparinized blood. Results. Hepatitis viruses carriers (groups 1 and 2) had significantly elevated circulating IFN level and deep immunocytes IFN producing ability down regulation. In HBV+ RA pts and IFN production decrease was maximal (degree III), in HCV+ RA pts - weaker (degree II). Conclusion. IFN status examination in pts with RA associated with hepatitis viruses and CGM has not only theoretical but also practical importance. Actuality of further study of this problem is determined by necessity of appropriate treatment selection considering IFN system pathology.https://rsp.mediar-press.net/rsp/article/view/1203rheumatoid arthritisinterferon systemcryoglobulinemia |
| spellingShingle | R M Balabanova E V Vralskih T P Ospelnikova V I Kiseleva Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses Научно-практическая ревматология rheumatoid arthritis interferon system cryoglobulinemia |
| title | Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses |
| title_full | Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses |
| title_fullStr | Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses |
| title_full_unstemmed | Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses |
| title_short | Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses |
| title_sort | interferon system in patients with rheumatoid arthritis infected with hepatitis в and с viruses |
| topic | rheumatoid arthritis interferon system cryoglobulinemia |
| url | https://rsp.mediar-press.net/rsp/article/view/1203 |
| work_keys_str_mv | AT rmbalabanova interferonsysteminpatientswithrheumatoidarthritisinfectedwithhepatitisvandsviruses AT evvralskih interferonsysteminpatientswithrheumatoidarthritisinfectedwithhepatitisvandsviruses AT tpospelnikova interferonsysteminpatientswithrheumatoidarthritisinfectedwithhepatitisvandsviruses AT vikiseleva interferonsysteminpatientswithrheumatoidarthritisinfectedwithhepatitisvandsviruses |