Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma

Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma

Leptin, one of the main hormones controlling energy homeostasis, has been associated with different cancer types. In oral cancer, its effect is not well understood. We investigated, through in vitro and in vivo assays, whether leptin can affect the neoplastic behavior of oral squamous cell carcinoma...

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Main Authors: Eliane Macedo Sobrinho Santos, Talita Antunes Guimarães, Hércules Otacílio Santos, Lilian Mendes Borborema Cangussu, Sabrina Ferreira de Jesus, Carlos Alberto de Carvalho Fraga, Claudio Marcelo Cardoso, Sérgio Henrique Souza Santos, Alfredo Maurício Batista de Paula, Ricardo Santiago Gomez, André Luiz Sena Guimarães, Lucyana Conceição Farias
Format: Article
Language:English
Published: SAGE Publishing 2017-04-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317699130
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